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二苯并环庚酮

二苯并环庚酮用途

【用途一】
用作医药中间体
【用途二】
医药中间体，用于药物阿米替林的合成。

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二苯并环庚酮名称

[ CAS 号 ]:
1210-35-1

[ 中文名 ]:
10,11-二氢二苯并[a,b]环庚烯-5-酮

[ 英文名 ]:
Dibenzosuberone

[中文别名 ]:

[英文别名 ]:

5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-one
5H-Dibenzo[a,d]cyclohepten-5-one, 10,11-dihydro-
10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-one
Dibenzosuberone
EINECS 214-912-3
L C676 BV&T&J
MFCD00003587

二苯并环庚酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
378.3±0.0 °C at 760 mmHg

[ 熔点 ]:
32-34 °C(lit.)

[ 分子式 ]:
C₁₅H₁₂O

[ 分子量 ]:
208.255

[ 闪点 ]:
158.3±20.1 °C

[ 精确质量 ]:
208.088821

[ PSA ]:
17.07000

[ LogP ]:
4.45

[ 外观性状 ]:
透明至黄色液体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.618

[ 储存条件 ]:
室温，干燥

[ 水溶解性 ]:
insoluble

二苯并环庚酮MSDS

二苯并环庚酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP1149700

CHEMICAL NAME :: 5H-Dibenzo(a,d)cyclohepten-5-one, 10,11-dihydro-

CAS REGISTRY NUMBER :: 1210-35-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H12-O

MOLECULAR WEIGHT :: 208.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,186,1992 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 uL/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Behavioral - coma

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,186,1992

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二苯并环庚酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
HP1149700

[ 海关编码 ]:
29143900

二苯并环庚酮合成路线

二苯并环庚酮上下游产品

二苯并环庚酮上游产品

二苯并环庚酮下游产品

二苯并环庚酮制备

由邻β-苯乙基苯甲酸经环合而得。

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二苯并环庚酮海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

二苯并环庚酮文献

The control of impurities in amitriptyline hydrochloride using a reversed-phase hybrid stationary phase.

Pharmeur. Sci. Notes 2005(1) , 15-20, (2005)

An isocratic reversed-phase liquid chromatographic method is described using a hybrid column for the control of synthetic impurities potentially found in amitriptyline hydrochloride. The method has be...

Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.

J. Med. Chem. 56(1) , 241-53, (2013)

p38α mitogen-activated protein (MAP) kinase is a main target in drug research concerning inflammatory diseases. Nevertheless, no inhibitor of p38α MAP kinase has been introduced to the market. This mi...

Design, synthesis, and biological evaluation of novel disubstituted dibenzosuberones as highly potent and selective inhibitors of p38 mitogen activated protein kinase.

J. Med. Chem. 55(12) , 5868-77, (2012)

Synthesis, biological testing, structure-activity relationships (SARs), and selectivity of novel disubstituted dibenzosuberone derivatives as p38 MAP kinase inhibitors are described. Hydrophilic moiet...

更多文献

二苯并环庚酮

二苯并环庚酮用途

二苯并环庚酮名称

二苯并环庚酮物理化学性质

二苯并环庚酮MSDS

详细MSDS(安全技术说明书)

二苯并环庚酮毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

二苯并环庚酮安全信息

二苯并环庚酮合成路线

详细合成路线

二苯并环庚酮上下游产品

二苯并环庚酮上游产品

二苯并环庚酮下游产品

二苯并环庚酮制备

二苯并环庚酮海关

二苯并环庚酮文献

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