3-(2-chlorophenothiazin-10-yl)-N-methylpropan-1-amine

名称

[ CAS 号 ]:
1225-64-5

[ 英文名 ]:
3-(2-chlorophenothiazin-10-yl)-N-methylpropan-1-amine

[英文别名 ]:

N-Desmethylchlorpromazine
NOR1-CHLORPROMAZINE
10H-Phenothiazine-10-propanamine,2-chloro-N-methyl
UNII-O1G7LW1I5H
Norchlorpromazine
Chlorpromazine impurity D
2-chloro-N-methyl-10H-phenothiazine-10-propanamine
N-Monodesmethylchlorpromazine
N-(3-methylaminopropyl)-2-chlorophenothiazine

物理化学性质

[ 密度 ]:
1.229g/cm3

[ 沸点 ]:
458.2ºC at 760mmHg

[ 分子式 ]:
C₁₆H₁₇ClN₂S

[ 分子量 ]:
304.83800

[ 闪点 ]:
230.9ºC

[ 精确质量 ]:
304.08000

[ PSA ]:
40.57000

[ LogP ]:
5.00810

[ 蒸汽压 ]:
1.4E-08mmHg at 25°C

[ 折射率 ]:
1.627

安全信息

[ 海关编码 ]:
2934300000

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海关

[ 海关编码 ]: 2934300000

[ 中文概述 ]:
2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

文献

Prediction of drug responses in schizophrenia: a method using a test dose of chlorpromazine.

Psychiatry Clin. Neurosci. 51(4) , 217-22, (1997)

Thirty-seven newly admitted schizophrenic patients were treated with an open and flexible dosage of chlorpromazine for 3 months after receiving a test dose. Levels of chlorpromazine, demethylated chlo...

Concentrations of chlorpromazine and two of its active metabolites in plasma and cerebrospinal fluid of psychotic patients treated with fixed drug doses.

Psychopharmacology 73(1) , 55-62, (1981)

Efforts to find a correlation between serum levels of chlorpromazine (CPZ) and clinical effect have been rather unsuccessful, which could be due to fluctuations of CPZ and CPZ metabolite levels during...

[A microanalytical gas liquid chromatography method with a nitrogen-phosphorus detector in the assay of various psychotropic drugs of tricyclic structure and of their N-demethylated metabolites].

Boll. Soc. Ital. Biol. Sper. 60(9) , 1757-63, (1984)

Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The ...

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