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异THIPENDYL

异THIPENDYL用途

Prothipendyl hydrochloride 可用于老年人精神症状的研究 (比如焦虑)。

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异THIPENDYL名称

[ CAS 号 ]:
1225-65-6

[ 中文名 ]:
异THIPENDYL

[ 英文名 ]:
(dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride

[英文别名 ]:

Dominal hydrochloride
Dominal forte
Tolnate
Prothipendyl HCl
Prothipendyl hydrochloride
Azacon

异THIPENDYL生物活性

[ 描述 ]:

Prothipendyl hydrochloride 可用于老年人精神症状的研究 (比如焦虑)。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. J F FLEETWOOD, et al. The Treatment of Mental Symptoms in the Aged With Prothipendyl (Tolnate). J Coll Gen Pract. 1964 Sep;8(2):262-6.

异THIPENDYL物理化学性质

[ 分子式 ]:
C₁₆H₂₀ClN₃S

[ 分子量 ]:
321.86800

[ 精确质量 ]:
321.10700

[ PSA ]:
41.43000

[ LogP ]:
1.15470

异THIPENDYL毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU8750000

CHEMICAL NAME :: 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 1225-65-6

LAST UPDATED :: 199012

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H19-N3-S.Cl-H

MOLECULAR WEIGHT :: 321.90

WISWESSER LINE NOTATION :: T C666 BN DN ISJ B1Y1&N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 610 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1323 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972