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异龙脑

异龙脑用途

Isoborneol ((±)-Isoborneol) 是一种单萜醇,存在于许多药用植物的精油中,具有抗氧化作用。Isoborneol 具有抗病毒特性,是 1 型单纯疱疹病毒 (HSV-1) 的有效抑制剂。

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异龙脑名称

[ CAS 号 ]:
124-76-5

[ 中文名 ]:
异龙脑

[ 英文名 ]:
Isoborneol

[中文别名 ]:

[英文别名 ]:

exo-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol
2-Hydroxybornane
Borneol
)-Isoborneol
EINECS 204-712-4
bornyl alcohol
Baros camphor
MFCD00074821
endo-borneol
(1R,2S,4R)-(+)-Borneol

异龙脑生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> HSV

研究领域 >> 感染

研究领域 >> 神经疾病

[ 靶点 ]

HSV-1

[体外研究]

异龙脑((？)-异龙脑)对6-OHDA诱导的半胱氨酸天冬氨酸蛋白酶-3活性增加和细胞色素C从线粒体转移到胞浆的作用具有保护作用。异龙脑可防止6-OHDA降低Bax/Bcl-2比值[1]。

[参考文献]

[1]. Tian LL, Zhou Z, Zhang Q, et al. Protective effect of (+/-) isoborneol against 6-OHDA-induced apoptosis in SH-SY5Y cells. Cell Physiol Biochem. 2007;20(6):1019‐1032.

[2]. Armaka M, Papanikolaou E, Sivropoulou A, Arsenakis M. Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1. Antiviral Res. 1999;43(2):79‐92.

异龙脑物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
212.0±0.0 °C at 760 mmHg

[ 熔点 ]:
208-214ºC

[ 分子式 ]:
C₁₀H₁₈O

[ 分子量 ]:
154.249

[ 闪点 ]:
65.6±0.0 °C

[ 精确质量 ]:
154.135757

[ PSA ]:
20.23000

[ LogP ]:
2.71

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.502

[ 储存条件 ]:
室温，干燥

[ 水溶解性 ]:
insoluble

异龙脑MSDS

异龙脑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NP7300000

CHEMICAL NAME :: Isoborneol, DL-

CAS REGISTRY NUMBER :: 124-76-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H18-O

MOLECULAR WEIGHT :: 154.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,531,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,531,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03209

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,531,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0371 No. of Facilities: 1136 (estimated) No. of Industries: 3 No. of Occupations: 12 No. of Employees: 13463 (estimated) No. of Female Employees: 8811 (estimated)

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异龙脑安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H228-H315

[ 警示性声明 ]:
P210

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
F;Xi

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN1325 4.1/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
NP7300000

[ 危险类别 ]:
4.1

[ 海关编码 ]:
2906199090

异龙脑合成路线

异龙脑上下游产品

异龙脑上游产品

异龙脑下游产品

异龙脑海关

[ 海关编码 ]: 2906199090

[ 中文概述 ]:
2906199090. 其他环烷醇，环烯醇及环萜烯醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

异龙脑文献

Gas chromatography-mass spectrometry method optimized using response surface modeling for the quantitation of fungal off-flavors in grapes and wine.

J. Agric. Food Chem. 63(11) , 2877-85, (2015)

An optimized method for the quantitation of volatile compounds responsible for off-aromas, such as earthy odors, found in wine and grapes was developed. The method involved a fast and simple headspace...

Kinetics and mechanisms of the tropospheric reactions of menthol, borneol, fenchol, camphor, and fenchone with hydroxyl radicals (OH) and chlorine atoms (Cl).

J. Phys. Chem. A 116(16) , 4097-107, (2012)

Relative kinetic techniques have been used to measure the rate coefficients for the reactions of oxygenated terpenes (menthol, borneol, fenchol, camphor, and fenchone) and cyclohexanol with hydroxyl r...

Treatment with cardiotonic pills(®) after ischemia-reperfusion ameliorates myocardial fibrosis in rats.

Microcirculation 20(1) , 17-29, (2013)

The present study was designed to evaluate whether CP was beneficial in alleviating myocardial fibrosis following I/R injury.Sprague-Dawley rats were subjected to 30 minutes occlusion of the LADCA, fo...

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异龙脑