二丙基甲酮
二丙基甲酮用途
用作硝化纤维的溶剂，也用于有机合成
【用途二】
食用香料。用于配制菠萝蜜、康酿克、香蕉、热带水果等型香精。
二丙基甲酮名称
[ CAS 号 ]:
123-19-3
[ 中文名 ]:
4-庚酮
[ 英文名 ]:
4-Heptanone
[中文别名 ]:
[英文别名 ]:
- 4-Oxoheptane
- DI(N-PROPYL) KETONE
- Dipropyl ketone
- Di-n-propyl ketone
- Pyrokohlensaeure-dipropylester
- ketone, dipropyl
- dicarbonic acid dipropyl ester
- heptan-4-one
- MFCD00009403
- EINECS 204-608-9
二丙基甲酮物理化学性质
[ 密度 ]:
0.8±0.1 g/cm3
[ 沸点 ]:
144.0±0.0 °C at 760 mmHg
[ 熔点 ]:
-33 °C
[ 分子式 ]:
C7H14O
[ 分子量 ]:
114.186
[ 闪点 ]:
48.9±0.0 °C
[ 精确质量 ]:
114.104462
[ PSA ]:
17.07000
[ LogP ]:
1.97
[ 外观性状 ]:
无色至淡黄色液体
[ 蒸汽密度 ]:
3.94 (vs air)
[ 蒸汽压 ]:
5.2±0.2 mmHg at 25°C
[ 折射率 ]:
1.404
[ 储存条件 ]:
包装完整、轻装轻放,库房通风、远离明火、高温、与氧化剂分开存放
[ 稳定性 ]:
Stable. Flammable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents.
[ 水溶解性 ]:
4.6 g/L (20 ºC)
二丙基甲酮MSDS
二丙基甲酮毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MJ5600000
- CHEMICAL NAME :
- 4-Heptanone
- CAS REGISTRY NUMBER :
- 123-19-3
- BEILSTEIN REFERENCE NO. :
- 1699049
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C7-H14-O
- MOLECULAR WEIGHT :
- 114.21
- WISWESSER LINE NOTATION :
- 3V3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,286,1986
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,286,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3730 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2690 ppm/6H
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- 38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985. Volume(issue)/page/year: 2C,4764,1982
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 271 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 37,56,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5660 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,313,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 gm/kg/3W-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571116
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 130 gm/kg/13W-I
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571116 *** REVIEWS *** ACGIH TLV-TWA 233 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIPROPYL KETONE-air:10H TWA 50 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
二丙基甲酮安全信息
[ 符号 ]:
GHS02, GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H226-H332
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ 危害码 (欧洲) ]:
Xn:Harmful;
[ 风险声明 (欧洲) ]:
R10;R20
[ 安全声明 (欧洲) ]:
S24/25
[ 危险品运输编码 ]:
UN 2710 3/PG 3
[ WGK德国 ]:
2
[ RTECS号 ]:
MJ5600000
[ 包装等级 ]:
III
[ 危险类别 ]:
3
[ 海关编码 ]:
2914190090
二丙基甲酮合成路线
二丙基甲酮上下游产品
二丙基甲酮上游产品
二丙基甲酮下游产品
二丙基甲酮制备
1.精制方法：常混有其他酮类，一般用蒸馏法精制。也可以加硝酸银铵溶液搅拌，静置30分钟至不再呈色后水洗，无水硫酸钙干燥后蒸馏。
2. 在450ºC时丁酸通过沉淀碳酸钙制备。
3.制法：
参照上述3-戊酮的制备方法（参考书335），用正丁酸（2）880g（10mol）进行反应，得到4-庚酮（1）285g，bp142～143℃，收率46%。
4.制法：
于装有甲醛。回流冷凝器的反应瓶中，加入还原铁粉123g（2.2mol），正丁酸（2）370mL，
搅拌加热回流5h。改为蒸馏装置，氮气保护下加热蒸馏，后期可停止通氮气。强热使所有能馏出的全部馏出。粗品依次用10%的氢氧化钠溶液、水洗涤，无水硫酸钠干燥，旋转浓缩后，剩余物精馏，收集142～144℃的馏分，得4-庚酮（1）157～171g，收率69%～75%。
二丙基甲酮海关
[ 海关编码 ]: 2914190090
[ 中文概述 ]:
2914190090 其他不含其他含氧基的无环酮。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装
[ Summary ]:
2914190090 other acyclic ketones without other oxygen function。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
二丙基甲酮文献
Clin. Chem. 30(3) , 426-32, (1984)
Numerous low-Mr metabolites--including creatinine, citrate, hippurate, glucose, ketone bodies, and various amino acids--have been identified in 400- and 500-MHz proton nuclear magnetic resonance (1H N...
1,5-anhydroglucitol and postprandial hyperglycemia as measured by continuous glucose monitoring system in moderately controlled patients with diabetes.Diabetes Care 29(6) , 1214-9, (2006)
Postprandial hyperglycemia is often inadequately assessed in diabetes management. Serum 1,5-anhydroglucitol (1,5-AG) drops as serum glucose rises above the renal threshold for glucose and has been pro...
Can serum beta-hydroxybutyrate be used to diagnose diabetic ketoacidosis?Diabetes Care 31(4) , 643-7, (2008)
Current criteria for the diagnosis of diabetic ketoacidosis (DKA) are limited by their nonspecificity (serum bicarbonate [HCO(3)] and pH) and qualitative nature (the presence of ketonemia/ketonuria). ...
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥108.0/100ml
￥338.0/500ml
联系人：刘佳
产品详情：4-庚酮
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥需询单/1mg
￥需询单/1g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁李高志
产品详情：4-庚酮
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相关化合物
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