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氨鲁米特

氨鲁米特用途

Aminoglutethimide是芳香酶抑制剂，IC50为10 μM。

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氨鲁米特名称

[ CAS 号 ]:
125-84-8

[ 中文名 ]:
氨鲁米特

[ 英文名 ]:
Aminoglutethimide

[中文别名 ]:

[英文别名 ]:

Orimeten
UNII:0O54ZQ14I9
Cytadren
(RS)-Aminoglutethimide
2,6-Piperidinedione, 3-(4-aminophenyl)-3-ethyl-
MFCD00010122
EINECS 204-756-4
(±)-Aminoglutethimide
(±)-p-Aminoglutethimide
aminoglutethimide

氨鲁米特物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
457.4±45.0 °C at 760 mmHg

[ 熔点 ]:
152-154 °C(lit.)

[ 分子式 ]:
C₁₃H₁₆N₂O₂

[ 分子量 ]:
232.278

[ 闪点 ]:
230.4±28.7 °C

[ 精确质量 ]:
232.121185

[ PSA ]:
72.19000

[ LogP ]:
1.41

[ 外观性状 ]:
近乎于白色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.566

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
H2O: 0.2 mg/mL, slightly soluble

氨鲁米特MSDS

氨鲁米特毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA4026950

CHEMICAL NAME :: Glutarimide, 2-(p-aminophenyl)-2-ethyl-

CAS REGISTRY NUMBER :: 125-84-8

BEILSTEIN REFERENCE NO. :: 0210656

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H16-N2-O2

MOLECULAR WEIGHT :: 232.31

WISWESSER LINE NOTATION :: T6VMVTJ D2 DR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 20500 mg/kg/94W-I

TOXIC EFFECTS :: Blood - agranulocytosis

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 291,970,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 21 mg/kg/3D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 105,633,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 625 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,736,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3630 mg/kg

SEX/DURATION :: female 1-35 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 124,421,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5423 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 403 (estimated) No. of Female Employees: 179 (estimated)

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氨鲁米特安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
3249

[ WGK德国 ]:
3

[ RTECS号 ]:
MA4026950

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2925190090

氨鲁米特合成路线

氨鲁米特上下游产品

氨鲁米特上游产品

氨鲁米特下游产品

氨鲁米特海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

氨鲁米特文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

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