DBCO-PEG4-Biotin

DBCO-PEG4-Biotin用途

DBCO-PEG4-Biotin 是一种含生物素基团和 4 个 PEG 的 azadibenzocyclooctyne-biotin 衍生物。DBCO-PEG4-Biotin 是一种用途广泛的生物素酰化试剂,能通过无铜催化烷基叠氮化反应 (SPAAC) 将生物素的一部分引入叠氮标记的生物分子中。

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DBCO-PEG4-Biotin名称

[ CAS 号 ]:
1255942-07-4

[ 中文名 ]:
DBCO-PEG4-生物素

[ 英文名 ]:
DBCO-PEG4-Biotin

[英文别名 ]:

DBCO-PEG4-Biotin生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[体外研究]

炔基在无铜键合化学反应中能与叠氮化物部分反应,形成稳定的三唑键。

[参考文献]

[1]. Hammink R, et al. Affinity-Based Purification of Polyisocyanopeptide Bioconjugates. Bioconjug Chem. 2017 Oct 18;28(10):2560-2568.

DBCO-PEG4-Biotin物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
1062.4±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₉H₅₁N₅O₈S

[ 分子量 ]:
749.916

[ 闪点 ]:
596.3±34.3 °C

[ 精确质量 ]:
749.345825

[ PSA ]:
181.86000

[ LogP ]:
1.72

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.620

[ 储存条件 ]:
-20°C

DBCO-PEG4-Biotin安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

DBCO-PEG4-Biotin文献

Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones.

J. Am. Chem. Soc. 11th ed., 132 , 3688-3690, (2010)

Bioorthogonal chemical reactions, those that do not interact or interfere with biology, have allowed for exploration of numerous biological processes that were previously difficult to study. The react...

Copper-free click chemistry for dynamic in vivo imaging.

Proc. Natl. Acad. Sci. U. S. A. 43th ed., 104 , 16793-16797, (2007)

Dynamic imaging of proteins in live cells is routinely performed by using genetically encoded reporters, an approach that cannot be extended to other classes of biomolecules such as glycans and lipids...

A comparative study of bioorthogonal reactions with azides.

ACS Chem. Biol. 10th ed., 1 , 644-648, (2006)

Detection of metabolites and post-translational modifications can be achieved using the azide as a bioorthogonal chemical reporter. Once introduced into target biomolecules, either metabolically or th...

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