氯丹

氯丹名称

[ CAS 号 ]:
12789-03-6

[ 中文名 ]:
氯丹(技术混合物)

[ 英文名 ]:
chlordan technical mixture pestanal

[中文别名 ]:

氯丹

氯丹物理化学性质

[ 密度 ]:
1.8g/cm3

[ 沸点 ]:
424.7ºC at 760mmHg

[ 熔点 ]:
106-107ºC

[ 分子式 ]:
C₁₀H₆Cl₈

[ 分子量 ]:
409.77900

[ 闪点 ]:
212.5ºC

[ 精确质量 ]:
405.79800

[ LogP ]:
5.68280

[ 蒸汽压 ]:
5.02E-07mmHg at 25°C

[ 折射率 ]:
1.627

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

氯丹毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FN5955000

CHEMICAL NAME :: Chlordane

CAS REGISTRY NUMBER :: 12789-03-6

LAST UPDATED :: 199609

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 283 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 880 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 144 mg/kg

SEX/DURATION :: female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 5 mg/L

REFERENCE :: AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980- Volume(issue)/page/year: 1,241,1980 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,115,1991 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,115,1991 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,115,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 51590 No. of Facilities: 1431 (estimated) No. of Industries: 17 No. of Occupations: 19 No. of Employees: 20937 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 51590 No. of Facilities: 387 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 3833 (estimated) No. of Female Employees: 574 (estimated)

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氯丹安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R21/22

[ 安全声明 (欧洲) ]:
36/37-60-61

[ 危险品运输编码 ]:
UN 2810 6.1/PG 3

[ RTECS号 ]:
FN5955000

氯丹制备

环戊二烯用氯气氯化，在40-60℃得到四氯环戊烷，进一步加热、通氯，得到多氯环戊烷，将其在汽化釜中气化后与氯气在500-560℃氯解得到六氯环戊二烯。六氯环戊二烯在55℃左右与环戊二烯反应生成氯啶，然后在80℃左右通氯，就得到氯丹