专利兰VF_MSDS_用途_熔点_专利兰VFCAS号【129-17-9】

专利蓝V(酸性蓝1)是一种新型的生物染料,可用作视网膜切除术的眼内染料。视网膜切除术是指切除半透明的内界膜(ILM)。在玻璃体视网膜手术中应用适当的染料可以达到完全切除的目的。专利蓝V可以用于对视网膜膜前结构进行染色。光谱分析表明,专利蓝V在450nm以下和600nm以上具有较强的吸收,呈现蓝绿色。专利蓝V也被用作淋巴管造影术中的标志物,用于肿瘤淋巴结的切除[1][2]。

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[ 描述 ]:

专利蓝V(酸性蓝1)是一种新型的生物染料,可用作视网膜切除术的眼内染料。视网膜切除术是指切除半透明的内界膜(ILM)。在玻璃体视网膜手术中应用适当的染料可以达到完全切除的目的。专利蓝V可以用于对视网膜膜前结构进行染色。光谱分析表明,专利蓝V在450nm以下和600nm以上具有较强的吸收,呈现蓝绿色。专利蓝V也被用作淋巴管造影术中的标志物,用于肿瘤淋巴结的切除[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. Mennel S, et al. Patent blue: a novel vital dye in vitreoretinal surgery. Ophthalmologica. 2006;220(3):190-3.

[2]. Barranger E, et al. Laparoscopic sentinel lymph node procedure using a combination of patent blue and radioisotope in women with cervical carcinoma. Cancer. 2003 Jun 15;97(12):3003-9.

[ 熔点 ]:
290ºC

[ 分子式 ]:
C₂₇H₃₁N₂NaO₆S₂

[ 分子量 ]:
566.665

[ 精确质量 ]:
566.152100

[ PSA ]:
137.41000

[ LogP ]:
5.92380

[ 外观性状 ]:
绿色蓝色粉末

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
1 g/20 mL (20 ºC)

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP6830000

CHEMICAL NAME :: Ammonium, (4-(alpha-(p-(diethylamino)phenyl)-2,4-disulfobenzyli dene)-2,5-cyclohexadi en-1- ylidene)diethyl-, hydroxide, monosodium salt

CAS REGISTRY NUMBER :: 129-17-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C27-H31-N2-O6-S2.Na

MOLECULAR WEIGHT :: 566.71

WISWESSER LINE NOTATION :: L6Y DYJ AUYR DN2&2&R BSWO DSWQ& DUK2&2 &-NA- &35/25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 33 ug/kg

TOXIC EFFECTS :: Immunological Including Allergic - anaphylaxis

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/m3/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3000 mg/kg/33W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2070 mg/kg/50W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4050 mg/kg/45W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 170,75,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,163,1978 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,163,1978 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0027 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 65 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0027 No. of Facilities: 5396 (estimated) No. of Industries: 45 No. of Occupations: 49 No. of Employees: 80939 (estimated) No. of Female Employees: 18204 (estimated)

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[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R45

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BP6830000

[ 海关编码 ]:
32041200

[ 海关编码 ]: 32041200

[Anaphylaxis to blue dyes].

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Evaluation of potential genotoxicity of five food dyes using the somatic mutation and recombination test.

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[Determination of sixteen food additives in beverage by capillary zone electrophoresis].

Se Pu 30(7) , 747-51, (2012)

A capillary zone electrophoretic (CZE) method for the separation of ten synthetic colorants such as acid red 92, patent blue V, uranine, acid red 1, indigo carmine, black BN, ponceau 6R, quinoline, am...

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