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L-乙硫胺酸

L-乙硫胺酸用途

L-Ethionine (L-ETH) 是一种氨基酸类及其衍生物。

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L-乙硫胺酸名称

[ CAS 号 ]:
13073-35-3

[ 中文名 ]:
L-乙硫氨酸

[ 英文名 ]:
Ethionine

[中文别名 ]:

[英文别名 ]:

Homocysteine S-Ethyl Ether
(S)-2-amino-4-(ethylthio)butanoic acid
L-2-amino-4-(ethylthio)butanoic acid
S-Ethyl-L-homocysteine
L-Homocysteine, S-ethyl-
(+)-S-ethyl-L-homocysteine
MFCD00002626
L-Homocysteine,S-ethyl-
(+)-ethionine
Ethionine

L-乙硫胺酸生物活性

[ 描述 ]:

L-Ethionine (L-ETH) 是一种氨基酸类及其衍生物。

[ 相关类别 ]:

研究领域 >> 其他

L-乙硫胺酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
310.4±37.0 °C at 760 mmHg

[ 熔点 ]:
280ºC (dec.)(lit.)

[ 分子式 ]:
C₆H₁₃NO₂S

[ 分子量 ]:
163.24

[ 闪点 ]:
141.5±26.5 °C

[ 精确质量 ]:
163.066696

[ PSA ]:
88.62000

[ LogP ]:
0.90

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.524

[ 储存条件 ]:
库房通风低温干燥

L-乙硫胺酸MSDS

L-乙硫胺酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES6825300

CHEMICAL NAME :: Butyric acid, 2-amino-4-(ethylthio)-, L-

CAS REGISTRY NUMBER :: 13073-35-3

BEILSTEIN REFERENCE NO. :: 1722528

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H13-N-O2-S

MOLECULAR WEIGHT :: 163.26

WISWESSER LINE NOTATION :: QVYZ2S2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44100 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 5 mmol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1059,1987

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L-乙硫胺酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
ES6825300

[ 海关编码 ]:
2930909090

L-乙硫胺酸合成路线

L-乙硫胺酸上下游产品

L-乙硫胺酸上游产品

L-乙硫胺酸下游产品

L-乙硫胺酸海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

L-乙硫胺酸文献

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

The Japanese toxicogenomics project: application of toxicogenomics.

Mol. Nutr. Food. Res. 54 , 218-27, (2010)

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted appr...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

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