三氧化二铁_MSDS_用途_密度_三氧化二铁CAS号【1309-37-1】

氧化铁、红色可以用作辅料,如着色剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。

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[ 描述 ]:

氧化铁、红色可以用作辅料,如着色剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用赋形剂还影响共同给药药物的吸收、分布、代谢和消除(ADME)过程[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

[ 密度 ]:
5.24

[ 熔点 ]:
1538ºC

[ 分子式 ]:
Fe₂O₃

[ 分子量 ]:
159.69

[ 闪点 ]:
>230°F

[ 精确质量 ]:
159.854630

[ PSA ]:
43.37000

[ 外观性状 ]:
红色至微红-棕色粉末

[ 储存条件 ]:
室温，干燥

[ 稳定性 ]:
Stable.

[ 水溶解性 ]:
INSOLUBLE

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NO7400000

CHEMICAL NAME :: Iron(III) oxide

CAS REGISTRY NUMBER :: 1309-37-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 44

MOLECULAR FORMULA :: Fe2-O3

MOLECULAR WEIGHT :: 159.70

WISWESSER LINE NOTATION :: FE2 O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ug/m3/24H/61D-C

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 50(7),73,1985 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 mg/kg

REFERENCE :: PBPHAW Progress in Biochemical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965- Volume(issue)/page/year: 14,47,1978 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3, Inhalable dust DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal NO EVIDENCE IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,29,1972 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,29,1972 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,216,1987 TOXICOLOGY REVIEW ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 78,99,1972 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:NUISANCE PARTICULATES DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,27,1973 OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 3 ppm (5 mg/m3) (fume) JAN 1993 OEL-AUSTRALIA:TWA 5 mg/m3 (fume) JAN 1993 OEL-BELGIUM:TWA 2 ppm (5 mg/m3) (fume) JAN 1993 OEL-DENMARK:TWA 3.5 mg/m3 (fume) JAN 1993 OEL-FINLAND:TWA 5 ppm (fume) JAN 1993 OEL-FRANCE:TWA 5 mg/m3 (fume) JAN 1993 OEL-GERMANY:TWA 6 mg/m3 (fume) JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3 (fume) JAN 1993 OEL-THE PHILIPPINES:TWA 10 mg/m3 (fume) JAN 1993 OEL-POLAND:TWA 5 mg/m3 (fume) JAN 1993 OEL-SWEDEN:TWA 3.5 mg/m3 (fume) JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (5 mg/m3) (fume) JAN 1993 OEL-THAILAND:TWA 10 mg/m3 (fume) JAN 1993 OEL-TURKEY:TWA 10 mg/m3 (fume) JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3 (total dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 (resp. dust) JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 (fume) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO IRON OXIDE, dust and fume (as Fe)-air:10H TWA 5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1463 No. of Facilities: 41132 (estimated) No. of Industries: 265 No. of Occupations: 153 No. of Employees: 483117 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1463 No. of Facilities: 62557 (estimated) No. of Industries: 308 No. of Occupations: 185 No. of Employees: 965275 (estimated) No. of Female Employees: 139397 (estimated)

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[ 符号 ]:

GHS02, GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H318

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338 + P310-P370 + P378-P403 + P235

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
UN 1376

[ WGK德国 ]:
-

[ RTECS号 ]:
NO7400000

[ 海关编码 ]:
2821100000

制法制备方法有湿法和干法。湿法制品结晶细小、颗粒柔软、较易研磨，适宜作颜料。干法制品结晶大、颗粒坚硬，适宜作磁性材料、抛光研磨材料。

1．湿法将一定量的5%硫酸亚铁溶液迅速与过量烧碱溶液反应（要求碱过量0.04～0.08g/mL），在常温下通入空气使之全部变成红棕色的氢氧化铁胶体溶液，作为沉积氧化铁的晶核。以上述晶核为载体，以硫酸亚铁为介质，通入空气，在75～85 ℃，在金属铁存在的条件下，硫酸亚铁与空气中氧作用，生成三氧化二铁（即铁红）沉积在晶核上，溶液中的硫酸根又与金属铁作用，重新生成硫酸亚铁，硫酸亚铁再被空气氧化成铁红继续沉积，如此循环到整个过程结束，生成氧化铁红。 2．干法硝酸与铁片反应生成硝酸亚铁，经冷却结晶，脱水干燥，经研磨后在600～700℃煅烧8～10 h，再经水洗、干燥、粉碎制得氧化铁红产品。也可以氧化铁黄为原料，经600～700℃煅烧制得氧化铁红。 3.从高纯硫酸亚铁水溶液出发，合成高纯α-FeO（OH）［12］，再在600℃温度下加热大约3h脱水则得α-Fe ₂O ₃。用这个方法得到的产品，每个粒子都具有次级结构的所谓膨体粒子。虽然乍看起来和母体结晶α-FeO（OH）具有同样大小的针状外形，但实际上是由极细小的一次粒子和空隙组成。加热分解温度越高，一次粒子的尺寸越大。而且也促进针状二次粒子间的烧结。 4.将氢氧化铁沉淀和蒸馏水一起装入聚四氟乙烯烧杯之后，在耐压管或热压锅中加热到150℃，就可得到由数微米尺寸的六角片状、单晶粒子组成的α-Fe ₂O ₃。这时，若热压锅的锅壁材质（不锈钢）不好，容易和水反应放出氢气。

由于发生的氢气使α-Fe₂O₃还原析出Fe₃O₄，不能制得纯α-Fe₂O₃。

4.采用硝酸亚铁氧化法。将稀硝酸和铁片反应生成硝酸亚铁，经空气氧化、压滤、漂洗、干燥、高温煅烧、粉碎而得。

5.将100kg工业硫酸亚铁用纯水加热溶解为相对密度为1.15～1.20的溶液，过滤后滤液应澄明清亮。将滤液加热沸腾，在搅拌下加入其体积6倍的，相对密度为1.08的工业草酸溶液（事先已过滤）：

加完草酸后静8h，使其反应完全并充分沉淀。然后分出上层酸液，沉淀用纯水反复倾洗至洗涤无SO₄^2-子存在，甩干，在100～110℃下干燥，过筛（40～60目），在高温炉中于400～500℃灼烧2h，趁热充分搅拌，冷却后，再次过筛，即得成品。

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[ 海关编码 ]: 2821100000

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