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灭菌丹

灭菌丹用途

Faltan 是一种二甲酰亚胺杀真菌剂,广泛用于葡萄树和一些蔬菜作物,对人支气管上皮细胞有毒性。
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灭菌丹名称

[ CAS 号 ]:
133-07-3

[ 中文名 ]:
灭菌丹

[ 英文名 ]:
Folpet

[中文别名 ]:

[英文别名 ]:

灭菌丹生物活性

[ 描述 ]:

Faltan 是一种二甲酰亚胺杀真菌剂,广泛用于葡萄树和一些蔬菜作物,对人支气管上皮细胞有毒性。

[ 相关类别 ]:

研究领域 >> 感染
信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. Canal-Raffin M, et al. Cytotoxicity of folpet fungicide on human bronchial epithelial cells. Toxicology. 2008 Jul 30;249(2-3):160-6.

灭菌丹物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
333.8±52.0 °C at 760 mmHg

[ 熔点 ]:
177-180°C

[ 分子式 ]:
C9H4Cl3NO2S

[ 分子量 ]:
296.56

[ 闪点 ]:
155.7±30.7 °C

[ 精确质量 ]:
294.902832

[ PSA ]:
62.68000

[ LogP ]:
2.85

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.693

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
practically insoluble

灭菌丹MSDS

详细MSDS(安全技术说明书)

灭菌丹毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TI5685000
CHEMICAL NAME :
Phthalimide, N-((trichloromethyl)thio)-
CAS REGISTRY NUMBER :
133-07-3
BEILSTEIN REFERENCE NO. :
0193373
LAST UPDATED :
199701
DATA ITEMS CITED :
52
MOLECULAR FORMULA :
C9-H4-Cl3-N-O2-S
MOLECULAR WEIGHT :
296.55
WISWESSER LINE NOTATION :
T56 BVNVJ CSXGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7540 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
68400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1546 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
750 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>22600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
437 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1000 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
500 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
491 mg/m3/4H
SEX/DURATION :
female 6-13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
900 mg/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
900 mg/kg
SEX/DURATION :
female 6-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
488 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
900 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Dominant lethal test

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
250 ug/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,233,1981 *** REVIEWS *** TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,3,1975 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0327 No. of Facilities: 608 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 1240 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0327 No. of Facilities: 628 (estimated) No. of Industries: 8 No. of Occupations: 21 No. of Employees: 10509 (estimated) No. of Female Employees: 1422 (estimated)
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灭菌丹安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H319-H332-H351-H400

[ 警示性声明 ]:
P261-P273-P280-P304 + P340 + P312-P333 + P313-P337 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
R20

[ 安全声明 (欧洲) ]:
S36/37-S46-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ RTECS号 ]:
TI5685000

[ 海关编码 ]:
2930909057

灭菌丹合成路线

详细合成路线

灭菌丹上下游产品

灭菌丹上游产品

灭菌丹下游产品

灭菌丹制备

1.三氯硫氯甲烷的制备 将配好的2%盐酸和计量的二硫化碳混合，搅拌通氯，控制氯气的流量，使其反应温度维持在26℃左右，并控制反应尾气的正常吸收和处理，一般需30h左右。最后静置分离出三氯硫氯甲烷，经水洗后供合成灭菌丹用。

2.邻苯二甲酰亚胺的制备由苯酐与碳酸氢铵共热制得。生产时将苯二甲酸酐与碳酸氢铵按3∶1（质量比）混合，后投入热熔罐中，用直接火加热，于300℃反应10～12h，由于这样操作不易控制，反应也不完全，且耗能，反应周期长，对环境有污染。因可采用将邻苯二甲酸酐加到氨水中溶解，生成二铵盐，把水分蒸出。再加热到较高温度进一步脱水，生成亚胺化合物。

3.灭菌丹的合成将4.5%的碱液计量加入缩合反应锅中，降温至－4℃，在激烈搅拌下投入过量的邻苯二甲酰亚胺溶液后，均匀滴加一定量的三氯硫氯甲烷，温度控制在-2℃左右，反应终点pH＝8，最后缩合物料经离心分离，水洗，气流干燥等后处理，制得灭菌丹。
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灭菌丹海关

[ 海关编码 ]: 2930909057

[ 中文概述 ]:
2930909057 灭菌丹、克菌丹、杀螨硫醚等〔包括氟杀螨、硫肟醚、莠不生〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2930909057 2-((trichloromethyl)thio)-3a,4,7,7a-tetrahydro-1h-isoindole-1,3(2h)-dione。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

灭菌丹文献

Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers.

J. Appl. Toxicol. 32(3) , 194-201, (2012)

The time courses of key biomarkers of exposure to captan and folpet was assessed in accessible biological matrices of orally exposed volunteers. Ten volunteers ingested 1  mg kg(-1) body weight of cap...

Air pollutants formed in thermal decomposition of folpet fungicide under oxidative conditions.

Environ. Sci. Technol. 45(2) , 554-60, (2011)

This contribution studies the decomposition of folpet fungicide under oxidative conditions and compares the product species with those of captan fungicide, which is structurally related to folpet. Tox...

Liquid chromatography-tandem mass spectrometry (LC/APCI-MS/MS) methods for the quantification of captan and folpet phthalimide metabolites in human plasma and urine.

Anal. Bioanal. Chem 399(6) , 2243-55, (2011)

Captan and folpet are fungicides largely used in agriculture. They have similar chemical structures, except that folpet has an aromatic ring unlike captan. Their half-lives in blood are very short, gi...


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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：灭菌丹

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区域：上海市奉贤区

价格：
￥128.0/1ml

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产品详情：灭菌丹标准溶液

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区域：上海市浦东新区

价格：
￥152.9/1ml ￥164.9/1ml ￥需询单/1g ￥需询单/1g

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产品详情：灭菌丹标准溶液

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相关化合物

【灭菌丹】化源网提供灭菌丹CAS号133-07-3，灭菌丹MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询灭菌丹上化源网，专业又轻松。>>电脑版：灭菌丹

标题：灭菌丹_MSDS_用途_密度_灭菌丹CAS号【133-07-3】_化源网 地址：https://m.chemsrc.com/mip/cas/133-07-3_746155.html