纳塞卡因

纳塞卡因用途

氯普鲁卡因(2-氯普鲁卡因)是Na,K-ATP酶活性的有效抑制剂,IC50为13mM。氯普鲁卡因阻断周围神经[1]。

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纳塞卡因名称

[ CAS 号 ]:
133-16-4

[ 中文名 ]:
氯普鲁卡因

[ 英文名 ]:
2-Diethylaminoethyl 4-amino-2-chloro-benzoate

[中文别名 ]:

[英文别名 ]:

2-(diethylamino)ethyl 4-amino-2-chlorobenzoate
Chloroprocainum
Piocaine
Chloroprocain
Nesacaine
Chlorprocain
2-Chloroprocaine
Halestyn
Chlorprocainum
Chlorprocaine

纳塞卡因生物活性

[ 描述 ]:

氯普鲁卡因(2-氯普鲁卡因)是Na,K-ATP酶活性的有效抑制剂,IC50为13mM。氯普鲁卡因阻断周围神经[1]。

[ 靶点 ]

IC50: 13 mM (Na,K-ATPase)[1]

[体内研究]

在小鼠中,盐酸氯普鲁卡因的静脉LD50为97 mg/kg,皮下LD50为950 mg/kg[2]。

[参考文献]

[1]. H Kutchai, et al. Inhibition of the Na,K-ATPase of Canine Renal Medulla by Several Local Anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403.

[2]. Chloroprocaine HCl Injection.

纳塞卡因物理化学性质

[ 密度 ]:
1.17g/cm3

[ 沸点 ]:
402.6ºC at 760mmHg

[ 分子式 ]:
C₁₃H₂₀Cl₂N₂O₂

[ 分子量 ]:
307.21600

[ 闪点 ]:
197.3ºC

[ 精确质量 ]:
306.09000

[ PSA ]:
55.56000

[ LogP ]:
3.80400

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
1.08E-06mmHg at 25°C

[ 折射率 ]:
1.553

[ 储存条件 ]:
2-8°C，密封，避光，惰性气体

纳塞卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG1575100

CHEMICAL NAME :: Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 133-16-4

BEILSTEIN REFERENCE NO. :: 2808071

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H19-Cl-N2-O2

MOLECULAR WEIGHT :: 270.79

WISWESSER LINE NOTATION :: ZR CG DVO2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 3,525,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9329 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 48 (estimated) No. of Female Employees: 48 (estimated)

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纳塞卡因安全信息

[ 海关编码 ]:
2922499990

纳塞卡因海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%