司班20

司班20用途

1.主要用于化妆品、医药、纺织业，作油包水型乳化剂、润湿剂及机械用润滑剂等。

2.以山梨醇为原料，经脱水闭环生成失水山梨醇后，再与月桂酸进行酯化反应制得。

3.非离子型表面活性剂，用作乳化剂、稳定剂、增稠剂、润滑剂、柔软剂、抗静电剂、分散剂、助溶剂、防锈剂、整理剂和纺纱助剂等。主要用于石油、精细化工、医药、农药、食品、化妆品、纺织业中。可单独使用，亦可同甘油酯、蔗糖脂等食品乳化剂共用，起协同效应。

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司班20名称

[ CAS 号 ]:
1338-39-2

[ 中文名 ]:
斯盘 20

[ 英文名 ]:
Span 20

[中文别名 ]:

[英文别名 ]:

emsorb2515
SPAN NO 20
(4ξ)-1,4-Anhydro-6-O-dodecanoyl-D-xylo-hexitol
Sorbitan laurate,Sorbitan monolaurate
Sorbitan M
MFCD00005365
Arlasel 20
SPAN(R) 20
D-GLUCITOL, 1,4-ANHYDRO-, 6-DODECANOATE
SPAN(TM) 20

司班20生物活性

[ 描述 ]:

山梨醇单十二烷酸酯是一种山梨醇酯表面活性剂。山梨醇单十二烷酸酯可用作赋形剂,如非离子表面活性剂、乳化剂等。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Brandner J D. The composition of NF-defined emulsifiers: Sorbitan monolaurate, monopalmitate, monostearate, monooleate, polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80[J]. Drug development and industrial pharmacy, 1998, 24(11): 1049-1054.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

司班20物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
516.1±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₈H₃₄O₆

[ 分子量 ]:
346.459

[ 闪点 ]:
176.9±22.2 °C

[ 精确质量 ]:
346.235535

[ PSA ]:
96.22000

[ LogP ]:
4.47

[ 外观性状 ]:
透明无色液体

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.504

[ 储存条件 ]:
室温

司班20MSDS

详细MSDS(安全技术说明书)

司班20毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG2920000

CHEMICAL NAME :: Sorbitan, monolaurate

CAS REGISTRY NUMBER :: 1338-39-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C18-H34-O6

MOLECULAR WEIGHT :: 346.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 33600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 720 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,519,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 112 gm/kg/2W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,519,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 336 gm/kg/6W-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,519,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3019 gm/kg/23W-C

TOXIC EFFECTS :: Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2(1),59,1960 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg/24W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 120,1075,1954

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2000 mg/kg/25W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

REFERENCE :: NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959- Volume(issue)/page/year: 10,489,1963 *** REVIEWS *** TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83354 No. of Facilities: 869 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 8185 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83354 No. of Facilities: 1627 (estimated) No. of Industries: 11 No. of Occupations: 28 No. of Employees: 34995 (estimated) No. of Female Employees: 22113 (estimated)

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司班20安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
WG2920000

[ 海关编码 ]:
34021300

司班20制备

1.以山梨醇为原料，经脱水闭环生成失水山梨醇后，再与月桂酸进行酯化反应制得。

或将山梨糖醇预先脱水，生成山梨糖醇酐，经精制再与月桂酸进行酯化反应制得：

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司班20海关

[ 海关编码 ]: 34021300

司班20文献

Fatty alcohols or fatty acids as niosomal hybrid carrier: effect on vesicle size, encapsulation efficiency and in vitro dye release.

Colloids Surf. B Biointerfaces 58(1) , 68-71, (2007)

Niosomal hybrid mixtures are prepared with bilayer stabilizer cholesterol from non-ionic surfactants span 20 (HLB value 8.6), span 60 (HLB 4.7) and span 85 (HLB 1.8) in presence of dicetyl phosphate (...

Effects of surfactant characteristics on drug availability from suppositories.

Pharmazie 63(6) , 459-63, (2008)

The addition of surfactants to suppository formulations is referred to in the scientific literature, but their effects on drug availability remain uncertain. Surfactants are reported to improve drug d...

A novel ionic liquid-in-oil microemulsion composed of biologically acceptable components: an excitation wavelength dependent fluorescence resonance energy transfer study.

J. Phys. Chem. B 117(11) , 3221-31, (2013)

In this work we have reported the formulation of a novel ionic liquid-in-oil (IL/O) microemulsion where the polar core of the ionic liquid, 1-ethyl-3-methylimidazolium n-butylsulfate ([C2mim][C4SO4]),...

更多文献

司班20

司班20用途

司班20名称

司班20生物活性

司班20物理化学性质

司班20MSDS

详细MSDS(安全技术说明书)

司班20毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

司班20安全信息

司班20制备

司班20海关

司班20文献

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