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8-氮鸟嘌呤

8-氮鸟嘌呤用途

8-Azaguanine 是显示抗肿瘤活性的嘌呤类似物。

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8-氮鸟嘌呤名称

[ CAS 号 ]:
134-58-7

[ 中文名 ]:
8-氮鸟嘌呤

[ 英文名 ]:
8-Azaguanine

[中文别名 ]:

[英文别名 ]:

EINECS 205-148-1
8-Azaguanine
MFCD00056937
5-amino-2,3-dihydrotriazolo[4,5-d]pyrimidin-7-one

8-氮鸟嘌呤生物活性

[ 描述 ]:

8-Azaguanine 是显示抗肿瘤活性的嘌呤类似物。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 癌症

[体外研究]

8-氮鸟嘌呤是一种嘌呤类似物,具有抗肿瘤活性。结果显示,与8-氮鸟嘌呤孵育后,细胞存活率以剂量和时间依赖性方式降低。在用8-氮鸟嘌呤处理24小时后,CEM细胞系的IC 50为约100μM,而对于MOLT3细胞系,IC 50为约10μM。用8-氮鸟嘌呤处理后,CEM和MOLT3细胞表面CD26表达增加,浓度依赖性[1]。

[细胞实验]

通过膜联蛋白V和碘化丙锭染色分析细胞凋亡和坏死的检测。在不存在或存在8-氮鸟嘌呤的情况下孵育后，洗涤细胞（以500×g离心5分钟）并在4℃下在含有5μL膜联蛋白V和5μL的440μL膜联蛋白缓冲液中孵育10分钟。碘化丙锭。然后洗涤细胞并重悬于磷酸盐缓冲盐水（PBS）中直至分析[1]。

[参考文献]

[1]. Dourado M, et al. CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukaemia cell lines in culture. Pathophysiology. 2007 May;14(1):3-10.

[相关活性小分子]

8-氮鸟嘌呤物理化学性质

[ 密度 ]:
2.6±0.1 g/cm3

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₄H₄N₆O

[ 分子量 ]:
152.114

[ 闪点 ]:
129.1ºC

[ 精确质量 ]:
152.044662

[ PSA ]:
113.34000

[ LogP ]:
-0.71

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.00149mmHg at 25°C

[ 折射率 ]:
2.308

[ 储存条件 ]:
库房通风低温干燥

8-氮鸟嘌呤MSDS

8-氮鸟嘌呤毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ6157000

CHEMICAL NAME :: 7H-v-Triazolo(4,5-d)pyrimidin-7-one, 5-amino-1,6-dihydro-

CAS REGISTRY NUMBER :: 134-58-7

LAST UPDATED :: 199709

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C4-H4-N6-O

MOLECULAR WEIGHT :: 152.14

WISWESSER LINE NOTATION :: T56 BNNM FVM INJ HZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD10 - Lethal Dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 50 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 80 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 80 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 30 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 80,165,1981 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

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8-氮鸟嘌呤安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XZ6157000

[ 海关编码 ]:
2933990090

8-氮鸟嘌呤合成路线

8-氮鸟嘌呤上下游产品

8-氮鸟嘌呤上游产品

8-氮鸟嘌呤下游产品

8-氮鸟嘌呤海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

8-氮鸟嘌呤文献

A Versatile Monoclonal Antibody Specific Against Human DAB2IP.

Monoclon. Antib. Immunodiagn. Immunother. 34 , 246-50, (2015)

Human DAB2 interaction protein (DAB2IP) is a member of Ras-GTPase activating protein family and functions as a tumor suppressor, implying it could serve as a prognostic biomarker in cancers. Here we g...

Preparation and preliminary application of monoclonal antibodies to the receptor binding region of Clostridium difficile toxin B.

Mol. Med. Report. 12 , 7712-20, (2015)

A previous nationwide Chinese epidemiological study revealed through isolation of A‑B+ Clostridium difficile strains, which produce toxin B (TcdB), but not toxin A TcdA, that the strains are widesprea...

Production and characterization of monospecific and bispecific antibodies against dengue virus NS1 protein.

J. Virol. Methods 220 , 5-12, (2015)

Dengue is a mosquito borne infection, which in recent years has become a major international public health concern. Annually, 100 million dengue virus infections are reported worldwide. The nonstructu...

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