【BW-B 70C】BW-B 70C CAS号:134470-38-5【结构式性质活性】-化源网

BW B70C是一种有效、选择性和口服活性花生四烯酸5-脂氧合酶抑制剂。BW B70C抑制豚鼠吸入过敏原后的急性和过敏性支气管收缩和晚期嗜酸性粒细胞聚集。BW B70C可防止白三烯C4的合成,减少白细胞向气道腔的迁移以及白蛋白微血管渗漏。BW B70C具有抗哮喘药物研究的潜力[1][2][3]。

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[ 描述 ]:

BW B70C是一种有效、选择性和口服活性花生四烯酸5-脂氧合酶抑制剂。BW B70C抑制豚鼠吸入过敏原后的急性和过敏性支气管收缩和晚期嗜酸性粒细胞聚集。BW B70C可防止白三烯C4的合成,减少白细胞向气道腔的迁移以及白蛋白微血管渗漏。BW B70C具有抗哮喘药物研究的潜力[1][2][3]。

[ 相关类别 ]:

研究领域 >> 其他

[体内研究]

BW B70C(30 mg/kg；i.p.)可防止肺泡巨噬细胞合成白三烯C4,并减少白细胞向气道腔的迁移以及白蛋白微血管渗漏,但不影响内毒素诱导的TNF-α和分泌型磷脂酶A2血水平的升高[2]。

[参考文献]

[1]. Yeadon M, et al. Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions. 1993 Jan;38(1-2):8-18.

[2]. Bureau MF, et al. 5-Lipoxygenase and endotoxin-induced microvascular albumin exchanges and leucocyte recruitment in guinea-pig lungs. Eur J Pharmacol. 1997 Apr 11;324(1):89-98.

[3]. Payne AN, et al. Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 1991;34:189-99.

[ 密度 ]:
1.295g/cm3

[ 沸点 ]:
498.9ºC at 760 mmHg

[ 分子式 ]:
C₁₇H₁₇FN₂O₃

[ 分子量 ]:
316.32700

[ 闪点 ]:
255.5ºC

[ 精确质量 ]:
316.12200

[ PSA ]:
75.79000

[ LogP ]:
4.48990

[ 蒸汽压 ]:
8.96E-11mmHg at 25°C

[ 折射率 ]:
1.627

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT3976666

CHEMICAL NAME :: Urea, N-(3-(3-(4-fluorophenoxy)phenyl)-1-methyl-2-propenyl) -N-hydroxy-

CAS REGISTRY NUMBER :: 134470-38-5

LAST UPDATED :: 199803

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H17-F-N2-O3

MOLECULAR WEIGHT :: 316.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg/14D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - interstitial nephritis

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 69,480,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg/7D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes primarily in glomeruli Kidney, Ureter, Bladder - proteinuria Blood - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 146,299,1997

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[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
YT3976666

Lyprinol inhibits LTB4 production by human monocytes.

Allerg. Immunol. (Paris.) 32(7) , 284-9, (2000)

The effect of Lyprinol was evaluated on LTB4-induced human monocytes (normal and allergic donors) activation. Peripheral blood normal monocyte-derived monocytes when stimulated by Interleukin-4 (IL-4)...

Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death.

J. Physiol. Pharmacol. 60(3) , 135-43, (2009)

Eryptosis, the suicidal death of erythrocytes, is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the erythrocyte surface. Eryptosis is triggered by in...

Allergen-induced glycoconjugate secretion in guinea-pig trachea in vivo: modulation by indomethacin, BW B70C and ZD-2138.

Pulm. Pharmacol. 8(1) , 53-63, (1995)

A method has been established for measurement of tracheal secretions in anaesthetized, ventilated guinea-pigs. The upper trachea was cannulated and perfused with saline. The perfusate was analysed for...

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公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥3669.0/10mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：BW-B 70C

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥1400.0/10mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：阿拉丁李高志

产品详情：BW-B 70C

公司名：上海创赛科技有限公司