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精胺氮氧化加合物

精胺氮氧化加合物用途

Spermine NONOate 是一种一氧化氮 (NO) 与精胺的复合物,作为 NO 的供体。Spermine NONOate 可用于 NO 的制备。

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精胺氮氧化加合物名称

[ CAS 号 ]:
136587-13-8

[ 中文名 ]:
精胺氮氧化加合物

[ 英文名 ]:
Spermine NONOate

[英文别名 ]:

精胺氮氧化加合物生物活性

[ 描述 ]:

Spermine NONOate 是一种一氧化氮 (NO) 与精胺的复合物,作为 NO 的供体。Spermine NONOate 可用于 NO 的制备。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

壬酸精胺在37℃和22-25℃下的半衰期分别为39分钟和230分钟[1]。

[参考文献]

[1]. A Ramamurthi , et al. Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem Res Toxicol. 1997 Apr;10(4):408-13.

[2]. K Homer, et al. In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur J Pharmacol. 1998 Aug 28;356(1):49-57.

精胺氮氧化加合物物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
425.4±55.0 °C at 760 mmHg

[ 熔点 ]:
105-107ºC

[ 分子式 ]:
C₁₀H₂₆N₆O₂

[ 分子量 ]:
262.352

[ 闪点 ]:
211.1±31.5 °C

[ 精确质量 ]:
262.211731

[ PSA ]:
120.21000

[ LogP ]:
-1.03

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.554

精胺氮氧化加合物安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22;S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2928000090

精胺氮氧化加合物合成路线

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精胺氮氧化加合物上下游产品

精胺氮氧化加合物上游产品

精胺氮氧化加合物下游产品

精胺氮氧化加合物海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

精胺氮氧化加合物文献

The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense.

Oncogene 34(14) , 1799-810, (2015)

Only humans and higher primates have high uric acid blood levels. Although high uric acid causes gout, it has been linked with human longevity because of its hypothetical antioxidant function. Recent ...

Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced α-Amy2/54 gene expression in GA-treated wheat aleurone layers.

Plant Mol. Biol. 81(1-2) , 27-40, (2013)

Here, α-Amy2/54 gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme oxygenase-1 (HO-1) in GA-treated wheat aleurone ...

S-Nitrosylation of NF-κB p65 Inhibits TSH-Induced Na(+)/I(-) Symporter Expression.

Endocrinology 156 , 4741-54, (2015)

Nitric oxide (NO) is a ubiquitous signaling molecule involved in a wide variety of cellular physiological processes. In thyroid cells, NO-synthase III-endogenously produced NO reduces TSH-stimulated t...

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