间型霉素B
间型霉素B名称
[ CAS 号 ]:
13877-76-4
[ 中文名 ]:
间型霉素B
[ 英文名 ]:
7H-Pyrazolo[4,3-d]pyrimidin-7-one,1,6-dihydro-3-b-D-ribofuranosyl-
[英文别名 ]:
- FORMYCIN B
- LAURUSIN
- OHYAMYCIN
间型霉素B物理化学性质
[ 密度 ]:
2.18g/cm3
[ 沸点 ]:
683.2ºC at 760mmHg
[ 分子式 ]:
C10H12N4O5
[ 分子量 ]:
268.22600
[ 闪点 ]:
367ºC
[ 精确质量 ]:
268.08100
[ PSA ]:
144.35000
[ 蒸汽压 ]:
1.34E-19mmHg at 25°C
[ 折射率 ]:
1.921
间型霉素B毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UR0800000
- CHEMICAL NAME :
- 7H-Pyrazolo(4,3-d)pyrimidin-7-one, 1,4-dihydro-3-beta-D-ribofuranosyl-
- CAS REGISTRY NUMBER :
- 13877-76-4
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C10-H12-N4-O5
- MOLECULAR WEIGHT :
- 268.26
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg/10D-I
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 umol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 30,2651,1981
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