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普那霉素IA

普那霉素IA用途

Pristinamycin IA是一个环肽大环内酯抗生素,属于链霉杀阳菌素,也是P-glycoprotein的底物。

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普那霉素IA名称

[ CAS 号 ]:
3131-03-1

[ 中文名 ]:
维及霉素B

[ 英文名 ]:
Virginiamycin B

[英文别名 ]:

Antibiotic PA 114B
Mikamycin B
Ostreogrycin B
PA 114B
Pristinamycin IA
Antibiotic PA 114 B1
Vernamycin BA
Mikamycin IA
Streptogramin B

普那霉素IA生物活性

[ 描述 ]:

Pristinamycin IA是一个环肽大环内酯抗生素,属于链霉杀阳菌素,也是P-glycoprotein的底物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

多肽产品

[参考文献]

[1]. Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16;288(2):187-92.

[相关活性小分子]

普那霉素IA物理化学性质

[ 密度 ]:
1.38g/cm3

[ 沸点 ]:
1202.1ºC at 760mmHg

[ 分子式 ]:
C₄₅H₅₄N₈O₁₀

[ 分子量 ]:
866.95800

[ 闪点 ]:
680.8ºC

[ 精确质量 ]:
866.39600

[ PSA ]:
227.96000

[ LogP ]:
2.13220

[ 储存条件 ]:
-20°C

普那霉素IA毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZA4870000

CHEMICAL NAME :: Virginiamycin S1, 4-(4(dimethylamino)-N-methyl-L-phenylalanine)-

CAS REGISTRY NUMBER :: 3131-03-1

BEILSTEIN REFERENCE NO. :: 0078387

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C45-H54-N8-O10

MOLECULAR WEIGHT :: 867.07

WISWESSER LINE NOTATION :: T F5-19-6 ANV DNV JNV MMV QOV TMV A&VTJ C1R DN1&1& D1 L2 P1 SR& OMV- BT6NJ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,367,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,750,1967

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普那霉素IA安全信息

[ 危险品运输编码 ]:
UN 3172

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)