环己基氨基磺酸钙
环己基氨基磺酸钙用途
环己基氨基磺酸钙名称
[ CAS 号 ]:
139-06-0
[ 中文名 ]:
环己基氨基磺酸钙
[ 英文名 ]:
Calcium bis(cyclohexylsulphamate)
[中文别名 ]:
[英文别名 ]:
- calciumsucaryl
- cacyclamate
- cyclamate,calciumsalt
- CYCLAMATE CALCIUM
- cylan
- kalziumzyklamate
- CALCIUM CYCLAMATE
- cyclan
- dietil
- sucarylcalcium
环己基氨基磺酸钙物理化学性质
[ 分子式 ]:
C12H24CaN2O6S2
[ 分子量 ]:
396.53700
[ 精确质量 ]:
396.07000
[ PSA ]:
155.22000
[ LogP ]:
3.68120
[ 外观性状 ]:
白色晶体
[ 储存条件 ]:
库房低温通风干燥
环己基氨基磺酸钙MSDS
环己基氨基磺酸钙毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GV7100000
- CAS REGISTRY NUMBER :
- 139-06-0
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 23
- MOLECULAR FORMULA :
- C12-H24-N2-O6-S2.Ca
- MOLECULAR WEIGHT :
- 396.58
- WISWESSER LINE NOTATION :
- L6TJ AMSWO 2 &-CA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada) ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 291 gm/kg/35D-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3465 gm/kg/88W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 45 gm/kg/66W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 55 mg/kg
- SEX/DURATION :
- female 1-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TEST SYSTEM :
- Rodent - gerbil
- DOSE/DURATION :
- 150 mg/kg
- REFERENCE :
- CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959- Volume(issue)/page/year: 13,189,1971 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,55,1980 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,55,1980 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,178,1987 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,1,1976 TOXICOLOGY REVIEW WMWOA4 Wiener Medizinische Wochenschrift. (Brueder Hollinek, Gallgasse 40, A-1130 Vienna, Austria) V.1- 1851- Volume(issue)/page/year: 121,515,1971
环己基氨基磺酸钙安全信息
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
26-36
[ RTECS号 ]:
GV7100000
环己基氨基磺酸钙制备
(1)由环己基氨基磺酸铵与氢氧化钙置换而成。
(2)以环己胺为原料,用氯磺酸或氨基磺酸磺化,氢氧化钙处理制取。
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