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盐酸恩布拉明

盐酸恩布拉明用途

Embramine (hydrochloride) 是用作抗组胺药和抗胆碱能活性分子的单乙醇胺。

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盐酸恩布拉明名称

[ CAS 号 ]:
13977-28-1

[ 中文名 ]:
盐酸恩布拉明

[ 英文名 ]:
embramine hydrochloride

[英文别名 ]:

Mebrophenhydramine hydrochloride
Bromadryl

盐酸恩布拉明生物活性

[ 描述 ]:

Embramine (hydrochloride) 是用作抗组胺药和抗胆碱能活性分子的单乙醇胺。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. J M Varga, et al. Mechanism of allergic cross-reactions--I. Multispecific binding of ligands to a mouse monoclonal anti-DNP IgE antibody. Mol Immunol. 1991, 28, 6.

盐酸恩布拉明物理化学性质

[ 沸点 ]:
405.8ºC at 760 mmHg

[ 分子式 ]:
C₁₈H₂₃BrClNO

[ 分子量 ]:
384.73800

[ 闪点 ]:
199.2ºC

[ 精确质量 ]:
383.06500

[ PSA ]:
12.47000

[ LogP ]:
5.09280

[ 蒸汽压 ]:
8.55E-07mmHg at 25°C

[ 储存条件 ]:
库房通风低温干燥

盐酸恩布拉明毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KQ8400000

CHEMICAL NAME :: Ethylamine, 2-((p-bromo-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N- dimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 13977-28-1

LAST UPDATED :: 199103

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H22-Br-N-O.Cl-H

MOLECULAR WEIGHT :: 384.78

WISWESSER LINE NOTATION :: ER DX1&R&O2N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,556,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,556,1989