盐酸酚妥拉明

盐酸酚妥拉明是一种口服活性肾上腺素能α受体阻断剂[1]。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 沸点 ]:
569ºC at 760 mmHg

[ 熔点 ]:
>230ºC(dec.)

[ 分子式 ]:
C₁₇H₂₀ClN₃O

[ 分子量 ]:
317.813

[ 闪点 ]:
297.9ºC

[ 精确质量 ]:
317.129486

[ PSA ]:
47.86000

[ LogP ]:
3.40680

[ 外观性状 ]:
powder | white to off-white

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
methanol: 10 mg/mL, clear, colorless

详细MSDS(安全技术说明书)

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SL0701000

CHEMICAL NAME :

Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphe nyl)amino)-, monohydrochloride

CAS REGISTRY NUMBER :

73-05-2

LAST UPDATED :

199009

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C17-H19-N3-O.Cl-H

MOLECULAR WEIGHT :

317.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1250 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

275 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

75 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 71,70,1949

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
UN 3249

[ WGK德国 ]:
3

[ RTECS号 ]:
SL0701000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4.

Br. J. Pharmacol. 171(23) , 5361-75, (2014)

This study examined the role of the main vascular cAMP-hydrolysing phosphodiesterases (cAMP-PDE) in the regulation of basal vascular tone and relaxation of rat aorta mediated by β-adrenoceptors, follo...

Arc-Expressing Neuronal Ensembles Supporting Pattern Separation Require Adrenergic Activity in Anterior Piriform Cortex: An Exploration of Neural Constraints on Learning.

J. Neurosci. 35 , 14070-5, (2015)

Arc ensembles in adult rat olfactory bulb (OB) and anterior piriform cortex (PC) were assessed after discrimination training on highly similar odor pairs. Nonselective α- and β-adrenergic antagonists ...

Noradrenaline-mediated facilitation of inhibitory synaptic transmission in the dorsal horn of the rat spinal cord involves interlaminar communications.

Eur. J. Neurosci. 42 , 2654-65, (2015)

In the dorsal horn of the spinal cord (DH), noradrenaline (NA) is released by axons originating from the locus coeruleus and induces spinal analgesia, the mechanisms of which are poorly understood. He...

更多文献

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥3564.0/500mg ￥978.0/100mg ￥293.0/25mg

联系人：夏言

产品详情：[Perfemiker]盐酸酚妥拉明,≥98%

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公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥262.9/25mg ￥746.9/100mg ￥3197.9/500mg ￥需询单/1g

联系人：阿拉丁

产品详情：盐酸苯酚胺

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