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哌嗪(六水)

哌嗪(六水)用途

用于医药及有机化合物的合成

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哌嗪(六水)名称

[ CAS 号 ]:
142-63-2

[ 中文名 ]:
哌嗪(六水)

[ 英文名 ]:
Piperazine Hexahydrate

[中文别名 ]:

[英文别名 ]:

Diethylenediamine Hexahydrate
piperazine,hexahydrate
Piperazine hydrate
Piperazine hexahydrate
EINECS 203-808-3
MFCD00149389

哌嗪(六水)物理化学性质

[ 密度 ]:
1.92g/cm3

[ 沸点 ]:
145-156 °C(lit.)

[ 熔点 ]:
42-44 °C(lit.)

[ 分子式 ]:
C₄H₂₂N₂O₆

[ 分子量 ]:
194.22700

[ 闪点 ]:
190 °F

[ 精确质量 ]:
194.14800

[ PSA ]:
79.44000

[ 外观性状 ]:
无色固体

[ 蒸汽压 ]:
4.05mmHg at 25°C

[ 储存条件 ]:
室温

[ 水溶解性 ]:
水溶性：可溶；可溶于：醇；极微溶：乙醚

哌嗪(六水)MSDS

详细MSDS(安全技术说明书)

哌嗪(六水)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM0850000

CHEMICAL NAME :: Piperazine, hexahydrate

CAS REGISTRY NUMBER :: 142-63-2

LAST UPDATED :: 199504

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C4-H10-N2.6H2-O

MOLECULAR WEIGHT :: 194.28

WISWESSER LINE NOTATION :: T6N DNTJ &QH 6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,336,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84706 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84706 No. of Facilities: 9 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 127 (estimated) No. of Female Employees: 45 (estimated)

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哌嗪(六水)安全信息

[ 符号 ]:

GHS05, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H317-H334-H361fd

[ 警示性声明 ]:
P260-P280-P284-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34;R42/43;R52/53

[ 安全声明 (欧洲) ]:
S22-S26-S36/37/39-S45-S61

[ 危险品运输编码 ]:
UN 2579 8/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
TM0850000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2933599090

哌嗪(六水)上下游产品

哌嗪(六水)上游产品

哌嗪(六水)下游产品

哌嗪(六水)制备

由氯乙醇经氨化、环合成哌嗪盐酸盐，再用氢氧化钠中和制得六水哌嗪，其反应式如下：

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哌嗪(六水)海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

哌嗪(六水)文献

Improved solvent formulations for efficient CO₂ absorption and low-temperature desorption.

ChemSusChem 5(9) , 1724-31, (2012)

This experimental study describes efficient CO₂ capture by 2-amino-2-methyl-1-propanol (AMP)/piperazine (PZ) in ethylene glycol monoethyl ether (EGMEE, 2-ethoxyethanol) containing approximately 15 wt ...

Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs.

Mini Rev. Med. Chem. 12(12) , 1282-92, (2012)

In addition to their antihistamine effects, H1-receptor antagonists possess pharmacological properties that are not uniformly distributed among this class of drugs, such as anti-inflammatory, anti-all...

Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.

J. Med. Chem. 56(6) , 2311-22, (2013)

On the basis of an initial molecular modeling study suggesting the favorable binding of the "privileged" fragment 8-hydroxyquinoline with HIV-1 integrase (IN) at the IN-lens epithelium-derived growth ...

更多文献

哌嗪(六水)

哌嗪(六水)用途

哌嗪(六水)名称

哌嗪(六水)物理化学性质

哌嗪(六水)MSDS

详细MSDS(安全技术说明书)

哌嗪(六水)毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

哌嗪(六水)安全信息

哌嗪(六水)上下游产品

哌嗪(六水)上游产品

哌嗪(六水)下游产品

哌嗪(六水)制备

哌嗪(六水)海关

哌嗪(六水)文献

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