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吡哌酸

吡哌酸用途

【用途一】
抗菌药，对绿脓杆菌、大肠杆菌、痢疾杆菌等革兰阴性杆菌有较强的抗菌作用，用于治疗急性尿路感染等病症
【用途二】
该品是第二代喹诺酮类抗菌药物的代表，与萘啶酸相比抗菌谱较广，用于泌尿道感染及耳鼻喉科感染等。
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吡哌酸名称

[ CAS 号 ]:
51940-44-4

[ 中文名 ]:
吡哌酸

[ 英文名 ]:
Pipemidic acid

[中文别名 ]:

[英文别名 ]:

吡哌酸生物活性

[ 描述 ]:

Pipemidic acid是一种新的抗菌剂, 抗绿脓杆菌。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌
研究领域 >> 感染

[相关活性小分子]

嘌呤霉素二盐酸盐 | G-418 硫酸盐 | 衣霉素 | 潮霉素B | 盐霉素 | 阿维巴坦钠 | 硫酸新霉素 | 法硼巴坦 | 甲氧西林钠 | 利福平 | 甲硝唑 | 羧苄青霉素钠 | 头孢他啶 | 盐酸依拉环素 | 头孢噻肟钠

吡哌酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
534.9±60.0 °C at 760 mmHg

[ 熔点 ]:
251-255℃

[ 分子式 ]:
C14H17N5O3

[ 分子量 ]:
303.316

[ 闪点 ]:
277.3±32.9 °C

[ 精确质量 ]:
303.133148

[ PSA ]:
100.35000

[ LogP ]:
-0.16

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.617

[ 储存条件 ]:
室温

吡哌酸MSDS

详细MSDS(安全技术说明书)

吡哌酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1153800
CHEMICAL NAME :
Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 5,8-dihydro-8-ethyl-5-oxo-2-(1-piperazinyl)-
CAS REGISTRY NUMBER :
51940-44-4
LAST UPDATED :
199612
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C14-H17-N5-O3
MOLECULAR WEIGHT :
303.36
WISWESSER LINE NOTATION :
T66 BN DN GV JNJ HVQ J2 C- DT6M DNTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
16 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1438 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
529 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1213 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
90 gm/kg/30D-I
TOXIC EFFECTS :
Cardiac - changes in heart weight Liver - changes in liver weight Endocrine - changes in thymus weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9100 mg/kg/26W-I
TOXIC EFFECTS :
Gastrointestinal - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22400 mg/kg
SEX/DURATION :
female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1400 mg/kg
SEX/DURATION :
female 8-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
22400 mg/kg
SEX/DURATION :
female 15-22 day(s) after conception lactating female 20 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
152 mg/kg
REFERENCE :
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,397,1988
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吡哌酸安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
42/43

[ 安全声明 (欧洲) ]:
22-36/37-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
UV1153800

吡哌酸合成路线

详细合成路线

吡哌酸上下游产品

吡哌酸上游产品

吡哌酸下游产品

吡哌酸制备

将2,4-二氯嘧啶-5-羧酸乙酯与β-乙氨基丙酸乙酯缩合环化为2-氯-5-羟基-7,8-二氢-8-乙基吡啶[2,3-d]嘧啶-6-羧酸酯。然后溴化后与哌嗪缩合、水解、中和而得吡哌酸。

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吡哌酸文献

Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002/657/EC. A systematic comparison of two different approaches: Liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spectrometry.

J. Chromatogr. A. 1379 , 83-91, (2015)

This work involved the optimization and validation of two methods according to the Commission Decision 2002/657/EC directives for determining fluoroquinolones residues in samples of poultry muscle and...

Improved sample treatment for the determination of 17 strong sorbed quinolone antibiotics from compost by ultra high performance liquid chromatography tandem mass spectrometry.

Talanta 138 , 247-57, (2015)

The use of compost from sewage sludge for agricultural application is nowadays increasing, since composting is recognized as one of the most important recycling options for this material, being a sour...

Ultra-high performance liquid chromatography-electrospray tandem mass spectrometry for the analysis of antibiotic residues in environmental waters.

Environ. Sci. Pollut. Res. Int. 22 , 16857-67, (2015)

An optimized solid-phase extraction (SPE) and ultra-high performance liquid chromatography-electrospray tandem mass spectrometry (UPLC-MS/MS) method was developed for the effective analysis of 35 anti...


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【吡哌酸】化源网提供吡哌酸CAS号51940-44-4，吡哌酸MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询吡哌酸上化源网，专业又轻松。>>电脑版：吡哌酸

标题：吡哌酸_MSDS_用途_密度_吡哌酸CAS号【51940-44-4】_化源网 地址：https://m.chemsrc.com/mip/cas/51940-44-4_1101655.html