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2-氨基-4-甲基-5-噻唑甲胺溴酸盐

2-氨基-4-甲基-5-噻唑甲胺溴酸盐用途

Amthamine 是一种组胺受体 (H1R-H4R) 激动剂。Amthamine 具有产生肝充血、肝细胞坏死活性。Amthamine 可用于H1R-H4激动剂对肝毒性的诱导作用研究。

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2-氨基-4-甲基-5-噻唑甲胺溴酸盐名称

[ CAS 号 ]:
142457-00-9

[ 中文名 ]:
2-氨基-4-甲基-5-噻唑甲胺溴酸盐

[ 英文名 ]:
Amthamine dihydrobromide

[英文别名 ]:

cc-388
Amthamine dihydrobromide
Hispidulin

2-氨基-4-甲基-5-噻唑甲胺溴酸盐生物活性

[ 描述 ]:

Amthamine 是一种组胺受体 (H1R-H4R) 激动剂。Amthamine 具有产生肝充血、肝细胞坏死活性。Amthamine 可用于H1R-H4激动剂对肝毒性的诱导作用研究。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Trivendra Tripathi, et al. Hepatotoxicity Due to Histamine Trifluoro-Methyl Toluidide, Amthamine, R-(-)-α-Methyl Histamine and Clobenpropit (H1R-H4R-Agonists, Respectively) in Rabbit Experimental Model. American Medical Journal. 2010, 1 (1): 1-7.

2-氨基-4-甲基-5-噻唑甲胺溴酸盐物理化学性质

[ 分子式 ]:
C₆H₁₃Br₂N₃S

[ 分子量 ]:
319.06

[ 精确质量 ]:
316.92000

[ PSA ]:
93.90000

[ LogP ]:
3.08150

2-氨基-4-甲基-5-噻唑甲胺溴酸盐MSDS

2-氨基-4-甲基-5-噻唑甲胺溴酸盐安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

2-氨基-4-甲基-5-噻唑甲胺溴酸盐合成路线

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2-氨基-4-甲基-5-噻唑甲胺溴酸盐文献

Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists.

Pharmacol. Rep. 62(5) , 917-25, (2010)

The present study was designed to delineate the immunomodulatory role of histamine receptors (H1R and H2R) and their antibody generation in a rabbit model. Six groups containing 18 rabbits each receiv...

Analysis of the histamine H2-receptor in human monocytes.

Biochem. Pharmacol. 92(2) , 369-79, (2014)

Histamine receptors are G-protein-coupled receptors (GPCRs). Canonically, the histamine H2-receptor (H2R) couples to Gs-proteins and activates adenylyl cyclases (ACs) with subsequent adenosine-3',5'-c...

Disruption of histamine H2 receptor slows heart failure progression through reducing myocardial apoptosis and fibrosis.

Clin. Sci. 127(7) , 435-48, (2014)

Histamine H2 receptor (H2R) blockade has been reported to be beneficial for patients with chronic heart failure (CHF), but the mechanisms involved are not entirely clear. In the present study, we asse...

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