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N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺

N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺用途

FGIN 1-27是一种吲哚乙酰胺,是一种特异性外周苯二氮卓受体(PBR)配体,Ki为5.0 nM。FGIN 1-27可以穿透血脑屏障(BBB)。FGIN 1-27可抑制异烟肼诱导的惊厥发作【1】。

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N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺名称

[ CAS 号 ]:
142720-24-9

[ 中文名 ]:
N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺

[ 英文名 ]:
FGIN-1-27

[英文别名 ]:

MFCD00467704
Fgin 1 27
Lopac-D-8555
Tocris-0658
N,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide

N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Michelle L James, et al. Development of ligands for the peripheral benzodiazepine receptor. Curr Med Chem. 2006;13(17):1991-2001.

N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺物理化学性质

[ 密度 ]:
1.073g/cm3

[ 沸点 ]:
608.3ºC at 760mmHg

[ 分子式 ]:
C₂₈H₃₇FN₂O

[ 分子量 ]:
436.60500

[ 闪点 ]:
321.7ºC

[ 精确质量 ]:
436.28900

[ PSA ]:
36.10000

[ LogP ]:
7.50570

[ 蒸汽压 ]:
9.6E-15mmHg at 25°C

[ 折射率 ]:
1.562

[ 储存条件 ]:
-20°C，密闭，干燥

N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺MSDS

N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺合成路线

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N,N-二己基-2-(4-氟苯)吲哚-3-乙酰胺文献

Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands.

Bioorg. Med. Chem. 12(2) , 423-38, (2004)

Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed. However, the physiol...

Translocator protein (18 kDa) as a pharmacological target in adipocytes to regulate glucose homeostasis.

Biochem. Pharmacol. 97 , 99-110, (2015)

As a major regulator in obesity and its associated metabolic complications, the proper functioning of adipocytes is crucial for health maintenance, thus serving as an important target for the developm...

Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway.

Br. J. Cancer 89(3) , 564-72, (2003)

Specific ligands of the peripheral benzodiazepine receptor (PBR) are known to induce apoptosis and cell cycle arrest in oesophageal cancer cells. However, the underlying mechanisms are still unknown. ...

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