纺锤菌素

纺锤菌素用途

Netropsin is a basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research. Netropsin is a polyamide with antibiotic and antiviral activity. It has been shown that Netropsin is active both against Gram-positive bacteria and Gram-negative bacteria.

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纺锤菌素名称

[ CAS 号 ]:
1438-30-8

[ 中文名 ]:
纺锤菌素

[ 英文名 ]:
Antibiotic 1142

[中文别名 ]:

纺锤霉素

[英文别名 ]:

t1384
Netropsin dihydrochloride
ia887
ch-777-a
Congocidin Sinanomycin
congocidin
ultrapuregrade
2814-a
antibiotic1142

纺锤菌素物理化学性质

[ 密度 ]:
1.52g/cm3

[ 沸点 ]:
544.74°C (rough estimate)

[ 熔点 ]:
171-173℃

[ 分子式 ]:
C₁₈H₂₆N₁₀O₃

[ 分子量 ]:
430.46400

[ 精确质量 ]:
430.21900

[ PSA ]:
208.93000

[ LogP ]:
1.62120

[ 外观性状 ]:
powder | faint yellow

[ 蒸汽压 ]:
1.75E-23mmHg at 25°C

[ 折射率 ]:
1.6500 (estimate)

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
H2O: 1 mg/mL

纺锤菌素MSDS

详细MSDS(安全技术说明书)

纺锤菌素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DW2973000

CHEMICAL NAME :: N,4'-Bi(pyrrole-2-carboxamide), N'-(2-carbamoylethyl)-4-((2-guanidinoacetimidoyl)amin o)-1,1'- dimethyl-

CAS REGISTRY NUMBER :: 1438-30-8

BEILSTEIN REFERENCE NO. :: 0376913

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H26-N10-O3

MOLECULAR WEIGHT :: 430.54

WISWESSER LINE NOTATION :: T5NJ A1 BVM2VZ EMV- BT5NJ A1 DMYUM&1MYZUM

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 500 umol/L

REFERENCE :: MLBRBU Molecular Biology Reports. (Dr. W. Junk Pub., POB 163, 3300 AD Dordrect, Netherlands) V.1- 1973- Volume(issue)/page/year: 2,135,1975

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纺锤菌素安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DW2973000