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6-(2-羟基-1-甲基-2-亚硝基肼)-N-甲基-1-己胺

用途

MAHMA NONOOATE是NO捐赠者。MAHMA NONOTE有效抑制胶原或ADP诱导的血小板聚集[1]。

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名称

[ CAS 号 ]:
146724-86-9

[ 中文名 ]:
1-HYDROXY-2-OXO-3(N-METHYL-6-AMINOHEXYL)-3-METHYL-1-TRIAZENE

[ 英文名 ]:
MAHMA NONOate

[英文别名 ]:

MFCD01310509
METHYLAMINE HEXAMETHYLENE METHYLAMINE NONOATE
noc-9crystalline
NOC-9
MAHMA/NO

生物活性

[ 描述 ]:

MAHMA NONOOATE是NO捐赠者。MAHMA NONOTE有效抑制胶原或ADP诱导的血小板聚集[1]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

[体外研究]

MAHMA NONOTE(0.1 nM-100μM)剂量依赖性地抑制胶原或ADP诱导的血小板聚集[1]。MAHMA NONOTE显示出对肺动脉和血小板聚集的抑制作用,对数IC50值分别为7.18和6.16[1]。

[体内研究]

MAHMA NONOTE(0.3-10 nmol/kg/min；静脉注射一次)在体内显示出血小板抑制和血管抑制作用[2]。动物模型：用戊巴比妥麻醉的雄性Wistar大鼠[2]剂量：0.3-10 nmol/kg/min给药：静脉注射；结果：剂量依赖性地降低平均全身动脉压,并显示出比GSNO更有效的作用。对0.3μ。

物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
301.7±44.0 °C at 760 mmHg

[ 熔点 ]:
102-108ºC

[ 分子式 ]:
C₈H₂₀N₄O₂

[ 分子量 ]:
204.270

[ 闪点 ]:
136.3±28.4 °C

[ 精确质量 ]:
204.158630

[ PSA ]:
68.17000

[ LogP ]:
0.44

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.503

[ 储存条件 ]:
20°C

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Salmonella enterica biofilm-mediated dispersal by nitric oxide donors in association with cellulose nanocrystal hydrogels.

AMB Express 5 , 28, (2015)

Protected by extracellular polymers, microbes within biofilms are significantly more resistant to disinfectants. Current research has been instrumental in identifying nitric oxide donors and hydrogels...

Organelle-Specific Nitric Oxide Detection in Living Cells via HaloTag Protein Labeling.

PLoS ONE 10 , e0123986, (2015)

Nitric oxide (NO) is a membrane-permeable signaling molecule that is constantly produced, transferred, and consumed in vivo. NO participates and plays important roles in multiple biological processes....

Effect of nitric oxide on VnfA, a transcriptional activator of VFe-nitrogenase in Azotobacter vinelandii.

J. Biochem. 157 , 365-75, (2015)

The transcriptional activator, VnfA, is necessary for the expression of the structural genes encoding vanadium-dependent nitrogenase in Azotobacter vinelandii. We have previously reported that VnfA ha...

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