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双氢奎尼丁盐酸盐

双氢奎尼丁盐酸盐用途

金鸡纳碱 [有机催化剂]

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双氢奎尼丁盐酸盐名称

[ CAS 号 ]:
1476-98-8

[ 中文名 ]:
氢鲲盐酸盐

[ 英文名 ]:
TCMDC-125509

[中文别名 ]:

[英文别名 ]:

hydroquinidine,monohydrochloride
Einecs 216-024-1
dihydrochinidinhydrochlorid
Hydroquinidine Hydrochloride
Hydroquindine Hydrochloride
Hydroquinidine HCl
TCMDC-125509
MFCD00135598
Dihydroquinidine Hydrochloride

双氢奎尼丁盐酸盐物理化学性质

[ 密度 ]:
1.2g/cm3

[ 沸点 ]:
498.4ºC at 760mmHg

[ 熔点 ]:
277-279ºC(lit.)

[ 分子式 ]:
C₂₀H₂₇ClN₂O₂

[ 分子量 ]:
362.894

[ 闪点 ]:
255.2ºC

[ 精确质量 ]:
362.176117

[ PSA ]:
45.59000

[ LogP ]:
4.13710

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
9.92E-12mmHg at 25°C

[ 储存条件 ]:
室温，干燥

双氢奎尼丁盐酸盐MSDS

详细MSDS(安全技术说明书)

双氢奎尼丁盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX3018000

CHEMICAL NAME :: Hydroquinidine, monohydrochloride

CAS REGISTRY NUMBER :: 1476-98-8

LAST UPDATED :: 199312

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H26-N2-O2.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 369 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,589,1977

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,589,1977

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 52,2797,1992

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双氢奎尼丁盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
UN 1544

[ RTECS号 ]:
MX3018000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

双氢奎尼丁盐酸盐文献

Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.

Antimicrob. Agents Chemother. 56(10) , 5356-64, (2012)

The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and ...

Modified asymmetric Strecker reaction of aldehyde with secondary amine: a protocol for the synthesis of S-clopidogrel (an antiplatelet agent).

J. Org. Chem. 77(16) , 7076-80, (2012)

A first approach for catalytic asymmetric Strecker reaction of aldehydes with a secondary amine in the presence of sodium fluoride using hydroquinine as chiral catalyst was developed. The catalytic sy...

Calculation of standard electrode potential of half reaction for benzoquinone and hydroquinone.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 65(2) , 333-9, (2006)

Geometric parameters, the vibrational frequencies and thermochemical values of benzoquinone and hydroquinone were computed using ab initio molecular orbital calculations (HF) and density function theo...

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