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4-甲氧基苯酚(MEHQ)

4-甲氧基苯酚(MEHQ)用途

Mequinol (4-Methoxyphenol) 是 Mercurialis spp 的生物活性成分之一,主要用于皮肤褪色。

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4-甲氧基苯酚(MEHQ)名称

[ CAS 号 ]:
150-76-5

[ 中文名 ]:
4-甲氧基苯酚

[ 英文名 ]:
Mequinol

[中文别名 ]:

[英文别名 ]:

HQMME
HYDROQUINONE METHYL ETHER
Phenol, p-methoxy-
Hydroquinone monomethyl ether
MEHQ
methylhydroquinone
Anisyl alcohol
p-Hydroxyanisole
Leucobasal
PHENOL,4-METHOXY

4-甲氧基苯酚(MEHQ)生物活性

[ 描述 ]:

Mequinol (4-Methoxyphenol) 是 Mercurialis spp 的生物活性成分之一,主要用于皮肤褪色。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Callender VD, et al. Postinflammatory hyperpigmentation: etiologic and therapeutic considerations. Am J Clin Dermatol. 2011 Apr 1;12(2):87-99.

4-甲氧基苯酚(MEHQ)物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
243.0±0.0 °C at 760 mmHg

[ 熔点 ]:
56 °C

[ 分子式 ]:
C₇H₈O₂

[ 分子量 ]:
124.137

[ 闪点 ]:
120.8±4.8 °C

[ 精确质量 ]:
124.052429

[ PSA ]:
29.46000

[ LogP ]:
1.31

[ 外观性状 ]:
粉红色晶体或白色蜡质固体

[ 蒸汽密度 ]:
4.3 (vs air)

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.535

[ 储存条件 ]:
库房低温,通风,干燥,防火,与强氧化剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with halogens, oxidizing agents.

[ 水溶解性 ]:
40 g/L (25 ºC)

4-甲氧基苯酚(MEHQ)MSDS

4-甲氧基苯酚(MEHQ)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL7700000

CHEMICAL NAME :: Phenol, p-methoxy-

CAS REGISTRY NUMBER :: 150-76-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 22

MOLECULAR FORMULA :: C7-H8-O2

MOLECULAR WEIGHT :: 124.15

WISWESSER LINE NOTATION :: QR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7508 ng/kg/12D-I

TOXIC EFFECTS :: Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 54,133,1986 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(5),31,1985 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg/m3 JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FRANCE:TWA 5 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 4-METHOXYPHENOL-air:10H TWA 5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3672 No. of Facilities: 9805 (estimated) No. of Industries: 136 No. of Occupations: 89 No. of Employees: 250087 (estimated) No. of Female Employees: 49763 (estimated)

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4-甲氧基苯酚(MEHQ)安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H317-H319-H361d-H412

[ 警示性声明 ]:
P201-P273-P280-P308 + P313-P333 + P313-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36;R43

[ 安全声明 (欧洲) ]:
S24/25-S26-S37/39-S46

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
SL7700000

[ 海关编码 ]:
2909500000

4-甲氧基苯酚(MEHQ)合成路线

4-甲氧基苯酚(MEHQ)上下游产品

4-甲氧基苯酚(MEHQ)上游产品

4-甲氧基苯酚(MEHQ)下游产品

4-甲氧基苯酚(MEHQ)制备

1.以对苯二酚为原料，用硫酸二甲酯作甲基化剂，或者在高温高压和催化下用甲醇作甲基化剂，均可制得4-甲氧基酚。另一种较新的方法是，在存在对苯醌的条件下由对苯二酚与甲醇反应。将甲醇和浓硫酸混合均匀，加入对苯二酚，加热回流，滴加对苯醌的甲醇溶液反应3h。冷却，用40%氢氧化钠溶液中和，滤除硫酸钠沉淀。滤液回收甲醇后用乙醚萃取，萃取液蒸去乙醚，再进行减压蒸馏，收集110-112℃（0.53kPa）馏分即得成品。收率为76%。

2.对硝基苯甲醚法　由对硝基氯苯经取代反应生成对硝基苯甲醚；再在还原剂Na2S的作用下还原生成对氨基苯甲醚；最后经重氮化反应，分解成产品对羟基苯甲醚。合成步骤如下。
对硝基氯苯合成对硝基苯甲醚　将带有回流冷凝管、搅拌器、温度计的250mL三颈瓶置于恒温槽中，加入39.4g（0.25mol）对硝基氯苯、100mL甲醇、2g聚乙二醇800，加热并搅拌，当有大量甲醇回流时，一次加入68.2g33.5%的NaOH溶液，升温至（78±0.5）℃，反应3h。趁热过滤于烧杯中，待稍冷后，往烧杯中加入60mL水，立即析出晶体，抽滤收集，干燥，称重得32.0g淡黄色固体。熔点54℃，产率83.6%。
对硝基苯甲醚合成对氨基苯甲醚　配制22%～23%Na2S溶液60g，加热到95℃后，再加入10g对硝基苯甲醚，搅拌，小心加热到100℃，对硝基苯甲醚在Na2S溶液中乳化、还原，反应6h。然后溶液沉降，将下层碱液排弃，将粗制的对氨基苯甲醚用热水洗涤3～4次，静置，趁热过滤，稍冷，结晶抽滤，干燥后，转入50mL克氏蒸馏瓶中，减压蒸馏，在5333～6665Pa收集145～150℃馏分，得微红色固体6.5g。熔点56～57℃，产率81%。

3. 烟草：OR，26；FC，18。

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4-甲氧基苯酚(MEHQ)海关

[ 海关编码 ]: 2909500000

[ 中文概述 ]:
2909500000. 醚酚、醚醇酚及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

4-甲氧基苯酚(MEHQ)文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

更多文献

4-甲氧基苯酚(MEHQ)

4-甲氧基苯酚(MEHQ)用途

4-甲氧基苯酚(MEHQ)名称

4-甲氧基苯酚(MEHQ)生物活性

4-甲氧基苯酚(MEHQ)物理化学性质

4-甲氧基苯酚(MEHQ)MSDS

详细MSDS(安全技术说明书)

4-甲氧基苯酚(MEHQ)毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

4-甲氧基苯酚(MEHQ)安全信息

4-甲氧基苯酚(MEHQ)合成路线

详细合成路线

4-甲氧基苯酚(MEHQ)上下游产品

4-甲氧基苯酚(MEHQ)上游产品

4-甲氧基苯酚(MEHQ)下游产品

4-甲氧基苯酚(MEHQ)制备

4-甲氧基苯酚(MEHQ)海关

4-甲氧基苯酚(MEHQ)文献

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