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2-氨基芴

2-氨基芴用途

2-氨基芴是一种合成化学杀虫剂。2-氨基芴是一种基因毒素。2-氨基芴可用于研究DNA加合物结构、DNA修复、致癌和诱变[1][4]。

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2-氨基芴名称

[ CAS 号 ]:
153-78-6

[ 中文名 ]:
2-氨基芴

[ 英文名 ]:
2-aminofluorene

[中文别名 ]:

[英文别名 ]:

9H-Fluoren-2-amine
EINECS 205-817-8
2-aminofluorene
2-Amino fluorene
9H-Fluoren-2-ylamine
MFCD00001125
2-Fluorenamine

2-氨基芴生物活性

[ 描述 ]:

2-氨基芴是一种合成化学杀虫剂。2-氨基芴是一种基因毒素。2-氨基芴可用于研究DNA加合物结构、DNA修复、致癌和诱变[1][4]。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

研究领域 >> 其他

[体外研究]

2-氨基芴(0-100μM,1-5天)对绵羊红细胞(SRBC)、DNP-Ficoll和LPS的抗体反应产生剂量相关的抑制[2]。2-氨基芴(0-100μM,3天,脾细胞)对LPS和Con A的淋巴细胞增殖反应产生抑制[2]。

[体内研究]

在快速乙酰化小鼠(C57BL/6J)中,2-氨基芴(60 mg/kg,i.p.)累积的2-氨基芴-DNA加合物是慢乙酰化剂(A/J)的两倍[3]。2-氨基芴(60 mg/kg,i.p.)在肿瘤靶器官中形成的DNA加合物水平明显高于乙酰化同族仓鼠的非靶器官[4]。

[参考文献]

[1]. Heflich RH, et al. Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites. Mutat Res. 1994 Oct;318(2):73-114.

[2]. Kim BS, et al. Immunosuppressive effects of 2-acetylaminofluorene and 2-aminofluorene on murine splenocytes culture. Drug Chem Toxicol. 1989 Sep-Dec;12(3-4):297-311.

[3]. Levy GN, et al. 2-Aminofluorene-DNA adduct formation in acetylator congenic mouse lines. Carcinogenesis. 1989 Apr;10(4):705-9.

2-氨基芴物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
379.3±21.0 °C at 760 mmHg

[ 熔点 ]:
124-128 °C(lit.)

[ 分子式 ]:
C₁₃H₁₁N

[ 分子量 ]:
181.233

[ 闪点 ]:
204.8±17.4 °C

[ 精确质量 ]:
181.089142

[ PSA ]:
26.02000

[ LogP ]:
2.88

[ 外观性状 ]:
白色至棕色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.697

[ 储存条件 ]:
存放于惰性气体之中;避免光,空气

[ 水溶解性 ]:
<0.1 g/100 mL at 19.5 ºC

2-氨基芴MSDS

2-氨基芴毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LL5075000

CHEMICAL NAME :: Fluoren-2-amine

CAS REGISTRY NUMBER :: 153-78-6

BEILSTEIN REFERENCE NO. :: 1945861

LAST UPDATED :: 199710

DATA ITEMS CITED :: 69

MOLECULAR FORMULA :: C13-H11-N

MOLECULAR WEIGHT :: 181.25

WISWESSER LINE NOTATION :: L B656 HHJ EZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 132 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3600 mg/kg/32W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 240 mg/kg/73W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg/26W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg/47W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 gm/kg/34W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4000 mg/kg/23W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3200 mg/kg/58W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2420 mg/kg/23W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg/

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 gm/kg/30W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1080 mg/kg/30W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Liver - tumors

TYPE OF TEST :: DNA repair

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - rabbit Lymphocyte

DOSE/DURATION :: 100 umol/L/30M

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,321,1978 *** REVIEWS *** TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,63,1970

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2-氨基芴安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R40;R68

[ 安全声明 (欧洲) ]:
S45-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LL5075000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29214980

2-氨基芴合成路线

2-氨基芴上下游产品

2-氨基芴上游产品

2-氨基芴下游产品

2-氨基芴制备

将2-硝基芴用锌粉还原。

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2-氨基芴海关

[ 海关编码 ]: 29214980

2-氨基芴文献

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Environ. Sci. Pollut. Res. Int. 22 , 19194-202, (2015)

The imazethapyr herbicide (formulation Verosil(®)) was evaluated for phytotoxicity and genotoxicity using a battery of bioassays: (1) the growth inhibition of the green alga Pseudokirchneriella subcap...

更多文献

2-氨基芴

2-氨基芴用途

2-氨基芴名称

2-氨基芴生物活性

2-氨基芴物理化学性质

2-氨基芴MSDS

详细MSDS(安全技术说明书)

2-氨基芴毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

2-氨基芴安全信息

2-氨基芴合成路线

详细合成路线

2-氨基芴上下游产品

2-氨基芴上游产品

2-氨基芴下游产品

2-氨基芴制备

2-氨基芴海关

2-氨基芴文献

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