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D-薄荷醇

D-薄荷醇用途

(+)-薄荷醇(D-薄荷脑)是薄荷醇的光学异构体之一。(+)-薄荷脑可在体外减少大鼠膈半横膈电诱发收缩。局部麻醉活动。(+)-薄荷醇还可以抑制铜绿微囊藻细胞的生长[1][2][3]。

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D-薄荷醇名称

[ CAS 号 ]:
15356-60-2

[ 中文名 ]:
D-薄荷醇

[ 英文名 ]:
D-Menthol

[中文别名 ]:

[英文别名 ]:

1S,3S,4R-(+)-menthol
(1S,2R,5S)-5-methyl-2-(1-methylethyl)cyclohexanol
Menthol, (1S,3S,4R)-(+)-
MFCD00062983
(1S,2R,5S)-2-Isopropyl-5-methylcyclohexanol
Menthol
(+)-Menthol
(+)-p-Menthan-3-ol
EINECS 239-387-8

D-薄荷醇生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

(+)-薄荷醇(0.0001-0.1μg/ml)在体外剂量依赖性地减少大鼠膈半膈肌的电诱发收缩,直至完全消除收缩。[1].

[参考文献]

[1]. Galeotti N, et al. Local anaesthetic activity of (+)- and (-)-menthol. Planta Med. 2001 Mar;67(2):174-6.

[2]. Galeotti N, et al. Menthol: a natural analgesic compound. Neurosci Lett. 2002 Apr 12;322(3):145-8.

[3]. Hu X, et al. Effects of d-menthol stress on the growth of and microcystin release by the freshwater cyanobacterium Microcystis aeruginosa FACHB-905. Chemosphere. 2014 Oct;113:30-5.

D-薄荷醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
215.4±8.0 °C at 760 mmHg

[ 熔点 ]:
43-44ºC

[ 分子式 ]:
C₁₀H₂₀O

[ 分子量 ]:
156.265

[ 闪点 ]:
93.3±0.0 °C

[ 精确质量 ]:
156.151413

[ PSA ]:
20.23000

[ LogP ]:
3.20

[ 外观性状 ]:
固体;White or Colorless powder to crystal

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.457

[ 储存条件 ]:
室温

D-薄荷醇MSDS

D-薄荷醇安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R37/38;R41

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
OT0700000

[ 海关编码 ]:
2906199090

D-薄荷醇合成路线

D-薄荷醇上下游产品

D-薄荷醇上游产品

D-薄荷醇下游产品

D-薄荷醇海关

[ 海关编码 ]: 2906199090

[ 中文概述 ]:
2906199090. 其他环烷醇，环烯醇及环萜烯醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

D-薄荷醇文献

Activation of human 5-hydroxytryptamine type 3 receptors via an allosteric transmembrane site.

Mol. Pharmacol. 87(1) , 87-95, (2015)

In common with other members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 receptors (5-HT3Rs) are activated by the binding of a neurotransmitter to an ext...

Corneal sensory nerve activity in an experimental model of UV keratitis.

Invest. Ophthalmol. Vis. Sci. 55(6) , 3403-12, (2014)

To produce in guinea pigs a UV-induced keratitis, to analyze the effects of this pathology on corneal nerve activity.In anesthetized animals, one eye was exposed to 254 nm UV-C radiation (500-1000 mJ/...

Effects of menthol on tobacco smoke exposure, nicotine dependence, and NNAL glucuronidation.

Cancer Epidemiol. Biomarkers Prev. 18(1) , 35-41, (2009)

Menthol is a controversial cigarette additive because its physiologic or pharmacologic effects may possibly increase the risk for cancer and its targeted market is the Black community. In a community-...

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