DL-苯丙醇胺盐酸盐
DL-苯丙醇胺盐酸盐用途
本品为鼻减充血剂，减食欲剂。
DL-苯丙醇胺盐酸盐名称
[ CAS 号 ]:
154-41-6
[ 中文名 ]:
DL-苯丙醇胺盐酸盐
[ 英文名 ]:
DL-Norephedrine hydrochloride
[中文别名 ]:
[英文别名 ]:
- NOREPHEDRINE HCL
- α-(1-Aminoethyl)benzyl alcohol hydrochloride
- a-Hydroxy-b-aminopropylbenzene Hydrochloride
- dl-NOREPHEDRINE HCl
- mucorama
- α-Hydroxy-β-aminopropylbenzene hydrochloride
- propadrinehydrochloride
- obestat
- a-(1-Aminoethyl)benzyl Alcohol Hydrochloride
- monydrin
DL-苯丙醇胺盐酸盐物理化学性质
[ 密度 ]:
1.071 g/cm3
[ 沸点 ]:
288.1ºC at 760 mmHg
[ 熔点 ]:
194-196 °C(lit.)
[ 分子式 ]:
C9H14ClNO
[ 分子量 ]:
187.667
[ 闪点 ]:
128.1ºC
[ 精确质量 ]:
187.076385
[ PSA ]:
46.25000
[ LogP ]:
2.56950
[ 外观性状 ]:
白色粉末
[ 蒸汽压 ]:
0.0011mmHg at 25°C
[ 折射率 ]:
1.557
[ 储存条件 ]:
?20°C
DL-苯丙醇胺盐酸盐MSDS
DL-苯丙醇胺盐酸盐毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DN4200000
- CHEMICAL NAME :
- Benzyl alcohol, alpha-(1-aminoethyl)-, hydrochloride, (+-)-
- CAS REGISTRY NUMBER :
- 154-41-6
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C9-H13-N-O.Cl-H
- MOLECULAR WEIGHT :
- 187.69
- WISWESSER LINE NOTATION :
- ZY1&YQR &GH -R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 2142 ug/kg
- TOXIC EFFECTS :
- Vascular - BP elevation not characterized in autonomic section
- REFERENCE :
- AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 85,339,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1490 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,284,1946
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 20,297,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 428 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,207,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,280,1946
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 275 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 9,203,1936
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 255 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,284,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,284,1946
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,284,1946
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 600 mg/kg
- TOXIC EFFECTS :
- Vascular - BP elevation not characterized in autonomic section
- REFERENCE :
- JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 52,3317,1930 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 6400 ug/kg
- SEX/DURATION :
- female 16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 2,295,1972 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2921 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 427 (estimated) No. of Female Employees: 176 (estimated)
DL-苯丙醇胺盐酸盐安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302
[ 警示性声明 ]:
P301 + P312 + P330
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
R22
[ 安全声明 (欧洲) ]:
S22-S36/37/39-S45
[ 危险品运输编码 ]:
UN 2811
[ WGK德国 ]:
3
[ RTECS号 ]:
DN4200000
[ 海关编码 ]:
2922199090
DL-苯丙醇胺盐酸盐合成路线
DL-苯丙醇胺盐酸盐上下游产品
DL-苯丙醇胺盐酸盐上游产品
DL-苯丙醇胺盐酸盐下游产品
DL-苯丙醇胺盐酸盐制备
美国专利2151517叙述的方法是：取 10.7 公斤 苯甲醛与 11.0 公斤 亚硫酸氢钠的 50 升 水溶液强力振摇，直至加成产物完全生成。同时，取 8.25 公斤 硝基乙烷溶于 4.5 公斤 苛性苏打的 20 升 水溶液中，将所得热溶液在强力搅拌下加至苯甲亚硫酸氢钠的稠液中，混合振摇半小时后放置过夜，从浮于上层的油状苯基硝基丙醇中，用 11.0 公斤 亚硫酸氢钠的 50 升 水溶液除少量未反应的苯甲醛。所得苯基硝基丙醇为无公油状物。重17.1 -17.7 公斤 ，沸点150 -165 ℃ （0.665千帕）。将基氢化并转化为盐酸盐，即为盐酸苯丙醇胺。
DL-苯丙醇胺盐酸盐海关
[ 海关编码 ]: 2922199090
[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
DL-苯丙醇胺盐酸盐文献
Forensic Sci. Int. 195(1-3) , 160-4, (2010)
Hallucinogenic mushrooms (e.g. Psilocybe and Panaeolus species) as well as leaves and young shoots of the khat tree (Catha edulis Forsk) are illicit drugs in many countries. The exact concentration of...
Keep an eye on the pupil: developing countries under chemical attack.Intern. Emerg. Med. 4(3) , 231-3, (2009)
Experiences with carrier-mediated transport in liquid-phase microextraction.
J. Chromatogr. Sci. 44(6) , 308-16, (2006)
Different organic borates, phosphates, sulphates, and carboxylic acids are evaluated as extraction carriers in three-phase liquid-phase microextraction (LPME). Hydrophilic basic drugs form ion-pairs w...
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