Omuralide

Omuralide用途

A potent 20S proteasome inhibitor with IC50 of 49 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity)..

点击显示

Omuralide名称

[ CAS 号 ]:
154226-60-5

[ 英文名 ]:
Omuralide

[英文别名 ]:

Tri-p-tolylstibine
Tri-p-tolylantimony
Clasto-Lactacystin Beta-lactone
Stibine,tri-p-tolyl
5,6,7,12,6'-pentamethoxy-2-methyl-berbam-1'-ene

Omuralide物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
462.9±45.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₁₅NO₄

[ 分子量 ]:
213.230

[ 闪点 ]:
233.7±28.7 °C

[ 精确质量 ]:
213.100113

[ PSA ]:
75.63000

[ LogP ]:
-1.40

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.534

Omuralide安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335

[ 警示性声明 ]:
P261-P301 + P310-P305 + P351 + P338

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

Omuralide合成路线

详细合成路线

Omuralide上下游产品

Omuralide上游产品

Omuralide下游产品

Omuralide文献

Proteasome inhibitor differentially regulates expression of the major immediate early genes of human cytomegalovirus in human central nervous system-derived cell lines.

Virus Res. 142(1-2) , 68-77, (2009)

Proteasome inhibitor, which inhibits NF-kappaB activation, has been reported to activate c-Jun N-terminal kinase (JNK)-c-Jun pathway. In this study, we investigated the effects of proteasome inhibitor...

Turnover of StAR protein: roles for the proteasome and mitochondrial proteases.

Mol. Cell. Endocrinol. 265-266 , 51-8, (2007)

Steroidogenic acute regulatory protein (StAR) is a mitochondrial protein essential for massive synthesis of steroid hormones in the adrenal and the gonads. Our studies suggest that once synthesized on...

Targeting of a chlamydial protease impedes intracellular bacterial growth.

PLoS Pathog. 7(9) , e1002283, (2011)

Chlamydiae are obligate intracellular bacteria that propagate in a cytosolic vacuole. Recent work has shown that growth of Chlamydia induces the fragmentation of the Golgi apparatus (GA) into ministac...

更多文献