BIBP3226 trifluoroacetate salt

BIBP3226 trifluoroacetate salt用途

BIBP3226是一种有效且选择性的神经肽Y Y1(NPY Y1)和神经肽FF(NPFF)受体拮抗剂,rNPY Y1、hNPFF2和rNPFF的Kis分别为1.1、79和108 nM。BIBP3226显示出类似焦虑的效应[1][2]。

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BIBP3226 trifluoroacetate salt名称

[ CAS 号 ]:
159013-54-4

[ 英文名 ]:
BIBP3226 trifluoroacetate salt

[英文别名 ]:

BIBP3226

BIBP3226 trifluoroacetate salt生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体

[体内研究]

BIBP3226(0.5,5μg；静脉注射；雄性Wistar大鼠)在较高剂量下诱导类似焦虑的效应[1]。

[参考文献]

[1]. Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4.

BIBP3226 trifluoroacetate salt物理化学性质

[ 分子式 ]:
C₂₇H₃₁N₅O₃

[ 分子量 ]:
473.56700

[ 精确质量 ]:
473.24300

[ PSA ]:
140.33000

[ LogP ]:
4.56130

[ 储存条件 ]:
-20°C

BIBP3226 trifluoroacetate saltMSDS

详细MSDS(安全技术说明书)

BIBP3226 trifluoroacetate salt安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

BIBP3226 trifluoroacetate salt文献

Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.

J. Neurosci. 34(35) , 11769-80, (2014)

Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hip...

Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP 3226.

J. Pharmacol. Exp. Ther. 275 , 136-142, (1995)

The present study was undertaken to investigate the in vitro and in vivo pharmacological profile of the novel, nonpeptide neuropeptide Y (NPY) Y1-selective antagonist, BIBP 3226 [(R)-N2-(diphenylacety...

Selective inhibition of neuropeptide Y Y1 receptors by BIBP3226 in rat and human epithelial preparations.

Eur. J. Pharmacol. 310 , 55-60, (1996)

BIBP3226 (N2-(diphenylacetyl)-N-[4-hydroxyphenyl)methyl]-D-arginine amide) has been used to examine the presence of neuropeptide Y Y1 receptors in 3 gastrointestinal epithelial preparations, namely th...

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