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帕拉米松乙酸酯

帕拉米松乙酸酯用途

醋酸参数沙松是一种合成糖皮质激素,具有抗炎和免疫抑制活性[1]。

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帕拉米松乙酸酯名称

[ CAS 号 ]:
1597-82-6

[ 中文名 ]:
帕拉米松乙酸酯

[ 英文名 ]:
Paramethasone Acetate

[中文别名 ]:

酸醋帕拉米松

[英文别名 ]:

PARAMETHASONE ACETATE
DSSTox_CID_3422
Paramethasone-21-acetate

帕拉米松乙酸酯生物活性

[ 描述 ]:

醋酸参数沙松是一种合成糖皮质激素,具有抗炎和免疫抑制活性[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

帕拉米松乙酸酯物理化学性质

[ 密度 ]:
1.29 g/cm1.29 g/cm3

[ 沸点 ]:
584.2ºC at 760 mmHg

[ 熔点 ]:
>148°C (dec.) (lit.)

[ 分子式 ]:
C₂₄H₃₁FO₆

[ 分子量 ]:
434.49800

[ 闪点 ]:
307.1ºC

[ 精确质量 ]:
434.21000

[ PSA ]:
100.90000

[ LogP ]:
2.32240

[ 外观性状 ]:
白色至米白色固体

[ 蒸汽压 ]:
4.42E-16mmHg at 25°C

[ 折射率 ]:
1.569

[ 储存条件 ]:
2-8°C

帕拉米松乙酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4025000

CHEMICAL NAME :: Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,17,21-trihydroxy-16-alpha-meth yl-, 21-acetate

CAS REGISTRY NUMBER :: 1597-82-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C24-H31-F-O6

MOLECULAR WEIGHT :: 434.55

WISWESSER LINE NOTATION :: L E5 B666 OV AHTTT&J A1 CQ E1 FV1OV1 FQ G1 LF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 392 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,588,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 10500 ug/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: NFGZAD Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku, Toyko 162, Japan) V.1- 1956- Volume(issue)/page/year: 13,211,1968

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 2625 ug/kg

SEX/DURATION :: female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)

REFERENCE :: NFGZAD Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku, Toyko 162, Japan) V.1- 1956- Volume(issue)/page/year: 13,211,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1177 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 297 (estimated)