2,3'-脱水胸苷

2,3'-无水硫脒；2'-脱氧-3',2-氢-5-甲基尿苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 密度 ]:
1.72g/cm3

[ 沸点 ]:
381.8ºC at 760mmHg

[ 熔点 ]:
246-247ºC

[ 分子式 ]:
C₁₀H₁₂N₂O₄

[ 分子量 ]:
224.21

[ 闪点 ]:
184.7ºC

[ 精确质量 ]:
208.08500

[ PSA ]:
64.35000

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
2.12E-07mmHg at 25°C

[ 折射率 ]:
1.735

详细MSDS(安全技术说明书)

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

详细合成路线

[3'-(Tetrazol-2''-yl-3'-deoxythymidine and its 5''-substituted form: synthesis and conformation in the crystalline state. Substrate properties of 3'-(tetrazol-2''-yl)-3'-deoxythymidine-5'-triphosphate in relation to DNA polymerases].

Bioorg. Khim. 21 , 49-54, (1995)

5''-Derivatives of 3'-(tetrazole-2''-yl)-3'-deoxythymidines were synthesized by interaction of 5'-benzoyl-2',3'-anhydrothymidine with tetrazole or its 5-derivatives followed by debenzoylation. Structu...

Study on disulfur-backboned nucleic acids: part 3. Efficient synthesis of 3',5'-dithio-2'-deoxyuridine and deoxycytidine.

Nucleosides Nucleotides Nucleic Acids 27 , 1272-1281, (2008)

A general method is described for synthesizing 3',5'-dithio-2'-deoxypyrimidine nucleosides 6 and 13 from normal 2'-deoxynucleosides. 2,3'-Anhydronucleosides 2 and 9 are applied as intermediates in the...

更多文献

暂无推荐供应商。请联系客服获知如何成为推荐供应商。