二环己烷并-18-冠醚-6
二环己烷并-18-冠醚-6用途
高效的相转移催化剂，多用于氧化、亲核取代、失羧、皂化、聚合及硼氢化钠或氢化铝锂参与的还原反应。
二环己烷并-18-冠醚-6名称
[ CAS 号 ]:
16069-36-6
[ 中文名 ]:
二环己烷并-18-冠醚-6
[ 英文名 ]:
Dicyclohexyl 18-crown-6
[中文别名 ]:
[英文别名 ]:
- DCH-18-crown-6
- cis-dicyclohexano-18-crown-6
- EINECS 240-216-4
- MFCD00005099
- Dicyclohexano-18-crown 6-Ether
- Dicyclohexyl 18-crown-6
- Dicyclohexo-18-crown-6
- dicyclohexyl-18-crown-6-ether
- dicyclohexyl-18-crown-6
- dicyclohexano-18-crown-6
二环己烷并-18-冠醚-6物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
508.0±45.0 °C at 760 mmHg
[ 熔点 ]:
47-50 °C
[ 分子式 ]:
C20H36O6
[ 分子量 ]:
372.496
[ 闪点 ]:
203.8±28.6 °C
[ 精确质量 ]:
372.251190
[ PSA ]:
55.38000
[ LogP ]:
2.28
[ 外观性状 ]:
白色至灰白色粉末
[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C
[ 折射率 ]:
1.443
[ 储存条件 ]:
2-8°C
[ 水溶解性 ]:
Slightly soluble
二环己烷并-18-冠醚-6MSDS
二环己烷并-18-冠醚-6毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HP5385000
- CHEMICAL NAME :
- Dibenzo(b,k)(1,4,7,10,13,16)hexaoxacyclooctadecin, eicosahydro-
- CAS REGISTRY NUMBER :
- 16069-36-6
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C20-H36-O6
- MOLECULAR WEIGHT :
- 372.56
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 176 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,408,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 55 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 192 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),72,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 53 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571202 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4575 mg/kg/61D-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), diffuse Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),72,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 910 mg/kg/26W-I
- TOXIC EFFECTS :
- Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),72,1987 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 105 mg/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - other effects to embryo
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),72,1987
二环己烷并-18-冠醚-6安全信息
[ 危害码 (欧洲) ]:
T:Toxic;
[ 风险声明 (欧洲) ]:
R23/24/25;R36/37/38
[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S38-S28A
[ 危险品运输编码 ]:
UN 2811 6.1/PG 3
[ WGK德国 ]:
3
[ RTECS号 ]:
HP5385000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1
[ 海关编码 ]:
29329995
二环己烷并-18-冠醚-6合成路线
二环己烷并-18-冠醚-6上下游产品
二环己烷并-18-冠醚-6上游产品
二环己烷并-18-冠醚-6下游产品
二环己烷并-18-冠醚-6制备
1.在1升不锈钢高压釜中加入125克(0.347摩尔)二苯并-1一冠一6，500毫升重蒸正丁醇和12.5克5%钉一三氧化二铝催化剂。通氮气冲洗系统三次后，通入氢气至70个大气压。在100℃搅拌下进行氢化，待吸氢量达到理论量(2.08摩尔)为止。冷至室温，排气，过滤，除去催化剂。滤液置于旋转蒸发器中，于减压下90一100℃浓缩，静置固化。将粗品溶于400毫升正庚烷，经7 x 20cm酸洗氧化铝(80-100目，活度I一l级)柱层析，正庚烷淋洗，收集在红外光谱中经基吸收峰出现前的组份。用旋转蒸发器蒸出溶剂，得75一89克(58一69%)白色棱柱形晶体，
2.制法：
于高压反应釜中，加入二苯基-18-冠-6（2）125g（0.347mol），500mL新蒸馏的丁醇-1,125g（5%）的钌-氧化铝催化剂。密闭后以氮气冲洗，再通入氢气。于100℃、0.7MPa压力下进行氢化，直至吸收的氢气达到理论量（2.08mol）。冷却至室温，放空，打开反应釜。滤去催化剂。滤液减压浓缩，剩余物放置后固化。将粗品溶于400mL正庚烷，过酸洗氧化铝柱，以正庚烷洗脱。洗脱后浓缩，得白色棱状结晶二环己基-18-冠-6①（1）的非对映异构体混合物75～89g，mp38～54℃，收率58%～69%。注：①本品有毒，对眼睛、皮肤有刺激性，使用时应特别注意安全。
二环己烷并-18-冠醚-6海关
[ 海关编码 ]: 2932999099
[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
相关化工产品/化学物质：
推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
产品详情：二环己烷并-18-冠醚-6
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥838.0/5g
￥248.0/1g
联系人：刘佳
产品详情：二环己烷并-18-冠醚-6
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥219.9/1g
￥909.9/5g
￥需询单/1g
￥需询单/1g
联系人：阿拉丁
产品详情：二环己烷并-18-冠醚-6
公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥321.0/1g
￥1384.0/5g
联系人：夏言
产品详情：[Perfemiker]二环己烷并-18-冠醚-6,98%
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