H-Leu-Leu-OMe·HCl

H-Leu-Leu-OMe·HCl用途

L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide 是人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物,可选择性消除具有细胞毒性潜能的淋巴细胞。L-Leucyl-L-Leucine methyl ester hydrobromide 也可以诱导溶酶体途径应激。

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H-Leu-Leu-OMe·HCl名称

[ CAS 号 ]:
16689-14-8

[ 中文名 ]:
Leu-leu甲酯氢溴酸

[ 英文名 ]:
L-Leucyl-L-Leucine methyl ester hydrobromide

[英文别名 ]:

LLME,HBr Leu-Leu-Ome,HBr

H-Leu-Leu-OMe·HCl生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[体外研究]

L-亮氨酸-L-亮氨酸甲酯(1 mM；0.5-2小时)增强MEF和A549细胞中LRRK2介导的Rab10和Rab12磷酸化[3]。L-亮氨酸-L-亮氨酸甲酯(10-250μ米；15分钟)被CD4-淋巴细胞转化为CCI3COOH不溶性产物[2]。

[参考文献]

[1]. Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48.

[2]. Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7.

[3]. Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423.

H-Leu-Leu-OMe·HCl物理化学性质

[ 分子式 ]:
C₁₃H₂₇BrN₂O₃

[ 分子量 ]:
339.26900

[ 精确质量 ]:
338.12100

[ PSA ]:
81.42000

[ LogP ]:
3.11300

[ 外观性状 ]:
固体

[ 储存条件 ]:
-20°C，密封，干燥

H-Leu-Leu-OMe·HClMSDS

详细MSDS(安全技术说明书)

H-Leu-Leu-OMe·HCl安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2924199090

H-Leu-Leu-OMe·HCl海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

H-Leu-Leu-OMe·HCl文献

Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614.

Immunopharmacology 49 , 285-294, (2000)

T614 (3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne) is a member of the family of methanesulfonanilide non-steroidal anti-inflammatory drugs (mNSAIDs), most of which act as cycl...

Engraftment capacity of mesenchymal cells following hematopoietic stem cell transplantation in patients receiving reduced-intensity conditioning regimen.

Leukemia 20 , 329-335, (2006)

The engraftment ability of mesenchymal cells was investigated in 26 patients receiving allogeneic transplantation from HLA-identical siblings with reduced-intensity conditioning (RIC). The stem cell s...

Use of granzyme B-based fluorescent protein reporters to monitor granzyme distribution and granule integrity in live cells.

Biol. Chem. 391 , 999-1004, (2010)

Reporter proteins comprising granzyme B (GrB) fused to eGFP, ecliptic pHluorin or mCherry, were generated and used to study granule (lysosome) distribution and properties in COS-1 cells and natural ki...

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