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氘代芘

氘代芘用途

芘-d10是氘标记的芘[1]。

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氘代芘名称

[ CAS 号 ]:
1718-52-1

[ 中文名 ]:
芘-同位素

[ 英文名 ]:
(2H10)Pyrene

[中文别名 ]:

[英文别名 ]:

Pyrene-d
[10-2H]Pyrene
Decadeuterio-pyren
decadeuteriopyrene
(2H10)Pyrene
Pyrene-d10
pyrene-1,2,3,4,5,6,7,8,9,10-d10
(H)Pyrene
L666 B6 2AB PJ &&d-10
perdeiteriopyrene

氘代芘生物活性

[ 描述 ]:

芘-d10是氘标记的芘[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

氘代芘物理化学性质

[ 密度 ]:
1.31 g/cm3

[ 沸点 ]:
404ºC at 760 mmHg

[ 熔点 ]:
145-148ºC(lit.)

[ 分子式 ]:
C₁₆D₁₀

[ 分子量 ]:
212.31200

[ 闪点 ]:
168.8ºC

[ 精确质量 ]:
212.14100

[ LogP ]:
4.58400

[ 外观性状 ]:
黄色或白色晶体和粉末

[ 蒸汽压 ]:
2.28E-06mmHg at 25°C

[ 折射率 ]:
1.851

[ 储存条件 ]:
Refrigerator

氘代芘MSDS

氘代芘安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R10;R22;R36;R37;R38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ WGK德国 ]:
3

[ 海关编码 ]:
28459000

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氘代芘文献

Distribution and Sources of Petroleum Hydrocarbons in Recent Sediments of the Imo River, SE Nigeria.

Arch. Environ. Contam. Toxicol. 70 , 372-82, (2016)

The distribution of aliphatic and aromatic hydrocarbons in surface sediments of the lower course of the Imo River (Nigeria) was investigated to determine the sources and fate of these compounds. The a...

Polycyclic Aromatic Acids Are Primary Metabolites of Alkyl-PAHs-A Case Study with Nereis diversicolor.

Environ. Sci. Technol. 49 , 5713-21, (2015)

Although concentrations of alkylated polycyclic aromatic hydrocarbons (alkyl-PAHs) in oil-contaminated sediments are higher than those of unsubstituted PAHs, only little attention has been given to me...

The effects of flow rate and temperature on SPMD measurements of bioavailable PAHs in seawater.

Mar. Pollut. Bull. 97 , 217-23, (2015)

This work investigates the dependence of the sampling rate (Rs) of semi-permeable membrane devices (SPMDs) on flow rate and temperature. The in situ Rs values were obtained using performance reference...

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氘代芘