18-冠醚-6
18-冠醚-6用途
18-冠醚-6名称
[ CAS 号 ]:
17455-13-9
[ 中文名 ]:
18-冠醚-6
[ 英文名 ]:
18-Crown-6
[中文别名 ]:
- 1,4,7,10,13,16-六氧杂环十八烷
- 18-冠-6-醚
- 18-冠-6,18-冠-6-醚
- 18-冠醚
- 王冠醚,18-冠-6,18-冠-6-醚
- 王冠醚
- 18-冠-6
- 十八冠醚-6
- 1,4,7,10,13,16-六氧环十八烷
[英文别名 ]:
- [18]crown-6
- EINECS 241-473-5
- 18-Crown-6
- 18-Crown 6-Ether
- 18-crown-6 ether
- UNII-63J177NC5B
- 1,4,7,10,13,16-Hexaoxacyclooctadecane
- ethylene oxide cyclic hexamer
- 1,4,7,10,13,16-Hexanoxacyclooctadecane
- 18-Crown ether-6
18-冠醚-6物理化学性质
[ 密度 ]:
1.0±0.1 g/cm3
[ 沸点 ]:
395.8±37.0 °C at 760 mmHg
[ 熔点 ]:
42-45 °C(lit.)
[ 分子式 ]:
C12H24O6
[ 分子量 ]:
264.315
[ 闪点 ]:
163.8±26.4 °C
[ 精确质量 ]:
264.157288
[ PSA ]:
55.38000
[ LogP ]:
-0.81
[ 外观性状 ]:
无色晶体
[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C
[ 折射率 ]:
1.404
[ 储存条件 ]:
Store at 0-5°C
[ 稳定性 ]:
Stable. Incompatible with strong acids, strong oxidizing agents.
[ 水溶解性 ]:
SOLUBLE
18-冠醚-6MSDS
18-冠醚-6毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MP4500000
- CHEMICAL NAME :
- 1,4,7,10,13,16-Hexanoxacyclooctadecane
- CAS REGISTRY NUMBER :
- 17455-13-9
- BEILSTEIN REFERENCE NO. :
- 1619616
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C12-H24-O6
- MOLECULAR WEIGHT :
- 264.36
- WISWESSER LINE NOTATION :
- T-18-O DO GO JO MO POTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 525 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(10),92,1988
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2500 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Gastrointestinal - other changes Liver - other changes
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536187
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 830 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intratracheal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536187
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 540 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(10),92,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 464 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 47,167,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3888 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Gastrointestinal - hypermotility, diarrhea Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571014
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 59 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(10),92,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg/15W-I
- TOXIC EFFECTS :
- Behavioral - tremor Related to Chronic Data - death Related to Chronic Data - changes in testicular weight
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536187
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 127 mg/kg/14D-I
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - changes in motor activity (specific assay) Related to Chronic Data - death
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0536187
18-冠醚-6安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302
[ 警示性声明 ]:
P301 + P312 + P330
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn:Harmful;
[ 风险声明 (欧洲) ]:
R20/22;R36
[ 安全声明 (欧洲) ]:
S26-S36-S39
[ 危险品运输编码 ]:
2811
[ WGK德国 ]:
3
[ RTECS号 ]:
MP4500000
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2932999099
18-冠醚-6合成路线
18-冠醚-6上下游产品
18-冠醚-6上游产品
18-冠醚-6下游产品
18-冠醚-6制备
1.通常采用威廉林合成法制取，即用醇盐与卤代烷反应。
2.制双(2一氯乙基)醚
在装有搅拌器、回流冷凝器、温度计和滴液漏斗的1升三颈烧瓶中，放置63.7克0.6摩尔)二甘醇、400毫升苯、102.8.克(1 .3摩尔)毗咤，在75℃搅拌下，于1.5小时内滴加155克(1.3摩尔)亚硫酸氯。继续回流12小时，用盐酸酸化至PH=2，分出出有机相，用无水硫酸钠千燥。过滤，蒸去溶剂后减压蒸馏，收集50-52℃/5-8mm的馏分，得76克(86%)双(2一氯乙基)醚，
3. 2.制18一冠一6
装置同上。在3升三颈烧瓶中，放置416克(约6.3摩尔)85%的粒状氢氧化钾、243克(1.25摩尔)四甘醇和1升四氢肤喃，徐徐加热15分钟后，在激烈搅拌下加入447克(3.125摩尔)双(2一氯乙基)醚与150毫升四氢吠喃配成的溶液。在搅拌下继续回流18小时。在减压下蒸出液剂，余下的棕色浆状物加750毫升二氯甲烷稀释。过滤，用100毫升二氯甲烷洗涤固体盐。合并虑液和洗液，加硫酸镁于燥。过滤，在减压下浓缩，然后在氮气存在下减压蒸馏，收集110-120/0.2mm的馏分.
(l).制1，8一二氯一3，6二氧杂辛烷
除用三甘醇代替二甘醇外，其余与制备双(2一氯乙基)醚相同。
(2).制18-冠一6
装置同上。在3升三颈烧瓶中，放置112.5克(102毫升，0.75摩尔)三甘醇和600毫升四氢吠喃，在搅拌下加入60%的氢氧化钾溶液[将109克85%(1.65摩尔)的粒状氢氧化钾溶于70毫升水中」.徐徐加热并激烈搅拌15分钟后，溶液开始变色而逐渐形成深棕色，加140.3克(0.75摩尔)1 ,8一二氯一3，6一二氧杂辛烷的100毫升四氢吠喃溶液，在激烈搅拌下回流18-24小时。冷却，在减压下蒸出大部分溶剂，然后加入500毫升二氯甲烷稀释余下的棕色浆状物.用砂芯漏斗过滤，二氯甲烷洗涤，合并滤液和洗液，加无水硫酸镁干燥。过滤，在减压下浓缩后高真空蒸馏，收集100一167℃/0.2mrn的馏分，主要馏分为含有76一78克(38一44%)18一冠一6的粗产物。通过多次小心蒸馏后重结晶(或升，或层析)，可得纯化产品。 纯化在250毫升锥形瓶中，放置50克18一冠一6粗产物100毫升乙精和磁力搅拌棒，然后装上氯化钙于燥管。将混合物搅拌成浆液，在电热板上加热溶解，随后在激烈搅拌下冷却至室温，让细小的白色晶体(冠醚一乙脐络合物)沉降。在冰箱中放置24一28小时后，在一30℃冷浴中静置，使络合物尽可能沉淀完全。在充氨干燥箱或充氮漏斗中快速过滤，用少量冷乙睛洗涤吸湿性结晶，然后转移到一个装有带活塞的导气管和磁力搅拌棒的200毫升园底烧瓶中，在0.1-0.5毫米真空中温热<~35℃)2一3小时，并不时搅拌，以除去络合物中的乙腊.
18-冠醚-6海关
[ 海关编码 ]: 2932999099
[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
18-冠醚-6文献
Analyst 140(6) , 1965-73, (2015)
We have developed a novel amino acid analysis method using derivatization of multiple functional groups (amino, carboxyl, and phenolic hydroxyl groups). The amino, carboxyl, and phenolic hydroxyl grou...
Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors.Nucl. Med. Biol. 41(6) , 524-35, (2014)
A radioligand for measuring the density of corticotropin-releasing factor subtype-1 receptors (CRF1 receptors) in living animal and human brain with positron emission tomography (PET) would be a usefu...
A novel 2-cyanobenzothiazole-based (18)F prosthetic group for conjugation to 1,2-aminothiol-bearing targeting vectors.Org. Biomol. Chem. 13(12) , 3667-76, (2015)
In a bid to find an efficient means to radiolabel biomolecules under mild conditions for PET imaging, a bifunctional (18)F prosthetic molecule has been developed. The compound, dubbed [(18)F]FPyPEGCBT...
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推荐生产厂家/供应商：
公司名：上海化源世纪贸易有限公司
区域：上海市普陀区
价格：
联系人：徐经理
公司名：上海吉至生化科技有限公司
区域：上海市奉贤区
价格：
￥228.0/100g
￥88.0/25g
￥768.0/500g
联系人：刘佳
产品详情：18-冠醚-6
公司名：上海阿拉丁生化科技股份有限公司
区域：上海市浦东新区
价格：
￥51.9/10g
￥139.9/100g
￥57.9/25g
￥599.9/500g
联系人：阿拉丁
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公司名：上海创赛科技有限公司
区域：上海市嘉定区
价格：
￥66.0/25g
￥180.0/100g
￥721.0/500g
联系人：夏言
公司名：中山市迪欣化工有限公司
区域：中山市三角镇
价格：
￥620.0/25kg
联系人：陈雪萍
产品详情：18-冠醚-6
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相关化合物
【18-冠醚-6】化源网提供18-冠醚-6CAS号17455-13-9，18-冠醚-6MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询18-冠醚-6上化源网，专业又轻松。>>电脑版：18-冠醚-6
标题：18-冠醚-6_MSDS_用途_密度_CAS号【17455-13-9】_化源网 地址：https://m.chemsrc.com/mip/cas/17455-13-9_749369.html