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五甘醇

五甘醇用途

Pentaethylene glycol 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

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五甘醇名称

[ CAS 号 ]:
4792-15-8

[ 中文名 ]:
五甘醇

[ 英文名 ]:
Pentaethylene glycol

[中文别名 ]:

[英文别名 ]:

Pentaethylene Glycol
3,6,9,12-Tetraoxatetradecane-1,14-diol,Pentaglycol
MFCD00002878
EINECS 225-341-4
pentaethyleneglycol
3,6,9,12-Tetraoxatetradecane-1,14-diol

五甘醇生物活性

[ 描述 ]:

Pentaethylene glycol 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

PEGs

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

五甘醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
356.1±32.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀H₂₂O₆

[ 分子量 ]:
238.278

[ 闪点 ]:
169.2±25.1 °C

[ 精确质量 ]:
238.141632

[ PSA ]:
77.38000

[ LogP ]:
-2.59

[ 外观性状 ]:
透明无色至黄色液体

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.458

[ 储存条件 ]:
室温，密封

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides.

五甘醇MSDS

五甘醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RZ2670000

CHEMICAL NAME :: Pentaethylene glycol

CAS REGISTRY NUMBER :: 4792-15-8

BEILSTEIN REFERENCE NO. :: 1635593

LAST UPDATED :: 199703

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H22-O6

MOLECULAR WEIGHT :: 238.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 22500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(12),77,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/m3/30D-I

TOXIC EFFECTS :: Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),86,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg/26W-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(12),77,1987

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五甘醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RZ2670000

[ 海关编码 ]:
2909499000

五甘醇合成路线

五甘醇海关

[ 海关编码 ]: 2909499000

[ 中文概述 ]:
2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

五甘醇文献

Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-β1.

Macromol. Biosci. 15 , 1035-44, (2015)

BMP-2 and TGF-β1 released from injectable thermoresponsive hydrogels are studied in the presence and absence of branched macromolecules bearing BMP-2 or TGF-β1 affinity binding peptides. The synthesiz...

Conformation and activity of lipase B from Candida antarctica in bicontinuous microemulsions.

Colloids Surf. B Biointerfaces 131 , 108-14, (2015)

The paper at hand deals with the influence of the pH-value on the conformation and activity of the lipase B from Candida antarctica (CalB) which is incorporated in a bicontinuous microemulsion. The mi...

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五甘醇