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阿嗪米特

阿嗪米特用途

阿嗪他胺(Bilipurum)可用于寻常型银屑病、消化不良等病症的研究[1][2]。

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阿嗪米特名称

[ CAS 号 ]:
1830-32-6

[ 中文名 ]:
阿嗪米特

[ 英文名 ]:
azintamide

[英文别名 ]:

Oragallin
Azinthiamide
Oragal
Oragalin
Oragallin purum
Biloral
Azintamid
Bilipurum
Colerin
Azintamide

阿嗪米特生物活性

[ 描述 ]:

阿嗪他胺(Bilipurum)可用于寻常型银屑病、消化不良等病症的研究[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Zhu L, et, al. [Efficacy and safety of compound azintamide on dyspepsia symptoms in a multicentre self-controlled trial]. Zhonghua Nei Ke Za Zhi. 2008 Nov;47(11):910-3.

[2]. Diezel W, et, al. [Azintamid as a therapeutic agent in psoriasis vulgaris - a therapeutic study]. Dermatol Monatsschr. 1983;169(8):521-4.

阿嗪米特物理化学性质

[ 密度 ]:
1.27g/cm3

[ 沸点 ]:
435.3ºC at 760 mmHg

[ 熔点 ]:
97ºC

[ 分子式 ]:
C₁₀H₁₄ClN₃OS

[ 分子量 ]:
259.76

[ 闪点 ]:
217ºC

[ 精确质量 ]:
259.05500

[ PSA ]:
71.39000

[ LogP ]:
2.09050

[ 蒸汽压 ]:
8.88E-08mmHg at 25°C

[ 折射率 ]:
1.573

阿嗪米特毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB5836500

CHEMICAL NAME :: Acetamide, 2-((6-chloro-3-pyridazinyl)thio)-N,N-diethyl-

CAS REGISTRY NUMBER :: 1830-32-6

BEILSTEIN REFERENCE NO. :: 0885011

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H14-Cl-N3-O-S

MOLECULAR WEIGHT :: 259.78

WISWESSER LINE NOTATION :: T6NNJ CG FS1VN2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,266,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,111,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,111,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,111,1974