2-keto-D-Glucose

2-keto-D-Glucose用途

2-Keto-D-Glucose (D-Glucosone) 是导致抗生素皮质酮的次级代谢途径中的关键中间体。2-Keto-D-Glucose 也是 D-葡萄糖转化为 D-果糖的中间产物。2-Keto-D-Glucose存在于各种天然来源中,包括真菌、藻类和贝类。

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2-keto-D-Glucose名称

[ CAS 号 ]:
1854-25-7

[ 中文名 ]:
D-葡糖醛酮

[ 英文名 ]:
2-Keto-D-Glucose

[中文别名 ]:

2-酮-d-葡萄糖

[英文别名 ]:

Arabino-hexosulose
D-arabino-hexosulose
Fructosone
arabino-Hexos-2-ulose
Mannosone
3-deoxyglucosone
(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexanal
D-Arabino-hexos-2-ulose
2-Keto-D-glucose
2-Ketoglucose

2-keto-D-Glucose生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[体外研究]

吡咯喹啉醌依赖的2-酮-D-葡萄糖(2KG)脱氢酶(2KGDH)对2-酮-D-葡萄糖氧化为2-酮-D-葡萄糖酸(2KGA)具有高度的特异性。P、金黄色素(Pa2KGDH)特别优选2KG作为底物,并氧化2KG的C-1位置,表明该酶为2KGDH[3]。

[参考文献]

[1]. Sun, Lianhong, et al. Engineering galactose oxidase to increase expression level in E. coli, enhance thermostability, and introduce novel activities. Dissertation (Ph.D.), California Institute of Technology.

[2]. zawa K, et al. A novel pyrroloquinoline quinone-dependent 2-keto-D-glucose dehydrogenase from Pseudomonas aureofaciens. J Bacteriol. 2015 Apr;197(8):1322-9.

[3]. Te-ning E.Liu, et al. Convenient, laboratory procedure for producing solid d-arabino-hexos-2-ulose (d-glucosone). Carbohydrate Research. Volume 113, Issue 1, 16 February 1983, Pages 151-157.

2-keto-D-Glucose物理化学性质

[ 密度 ]:
1.574 g/cm3

[ 沸点 ]:
481ºC at 760 mmHg

[ 熔点 ]:
118-120°C

[ 分子式 ]:
C₆H₁₀O₆

[ 分子量 ]:
178.14000

[ 闪点 ]:
258.8ºC

[ 精确质量 ]:
178.04800

[ PSA ]:
115.06000

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
2.85E-11mmHg at 25°C

[ 折射率 ]:
1.55

[ 储存条件 ]:
Hygroscopic, Store under Inert atmosphere -20°C Freezer

2-keto-D-Glucose安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
29144000

2-keto-D-Glucose文献

Peroxynitrite induces formation of N( epsilon )-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite.

Diabetes 51(9) , 2833-9, (2002)

Accumulation of advanced glycation end products (AGEs) on tissue proteins increases with pathogenesis of diabetic complications and atherosclerosis. Here we examined the effect of peroxynitrite (ONOO(...

Bioconversion of D-glucose into D-glucosone by glucose 2-oxidase from Coriolus versicolor at moderate pressures.

Appl. Biochem. Biotechnol. 163 , 906-917, (2011)

Glucose 2-oxidase (pyranose oxidase, pyranose:oxygen-2-oxidoreductase, EC 1.1.3.10) from Coriolus versicolor catalyses the oxidation of D-glucose at carbon 2 in the presence of molecular O₂ producing ...

Fungal pyranose oxidases: occurrence, properties and biotechnical applications in carbohydrate chemistry.

Appl. Microbiol. Biotechnol. 54 , 727, (2000)

Pyranose oxidases are widespread among lignin-degrading white rot fungi and are localized in the hyphal periplasmic space. They are relatively large flavoproteins which oxidize a number of common mono...

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