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西洛雷定盐酸盐

西洛雷定盐酸盐用途

Cilobradine是一种HCN通道阻断剂。

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西洛雷定盐酸盐名称

[ CAS 号 ]:
186097-54-1

[ 中文名 ]:
西洛雷定盐酸盐

[ 英文名 ]:
DK-AH 269

[中文别名 ]:

盐酸西洛雷定

[英文别名 ]:

DK-AH 269
DK-AH 269
Cilobradine (hydrochloride)

西洛雷定盐酸盐生物活性

[ 描述 ]:

Cilobradine是一种HCN通道阻断剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> HCN频道

研究领域 >> 心血管疾病

[参考文献]

[1]. Cheng L, et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Pharmacol Exp Ther. 2007 Sep;322(3):931-939.

[相关活性小分子]

N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐 | 盐酸Zatebradine

西洛雷定盐酸盐物理化学性质

[ 沸点 ]:
655.7ºC at 760 mmHg

[ 分子式 ]:
C₂₈H₃₉ClN₂O₅

[ 分子量 ]:
519.07300

[ 闪点 ]:
350.4ºC

[ 精确质量 ]:
518.25500

[ PSA ]:
60.47000

[ LogP ]:
4.28070

[ 蒸汽压 ]:
1.96E-17mmHg at 25°C

[ 储存条件 ]:
-20°C，密闭，干燥

西洛雷定盐酸盐MSDS

详细MSDS(安全技术说明书)

西洛雷定盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

西洛雷定盐酸盐文献

Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine.

Eur. J. Pharmacol. 478 , 161-171, (2003)

The action of the bradycardiac agents, cilobradine (DK-AH269) and zatebradine (UL-FS49), on the cardiac pacemaker current (If) was investigated on short Purkinje fibres from sheep hearts, using the tw...

Bradycardic and proarrhythmic properties of sinus node inhibitors.

Mol. Pharmacol. 69 , 1328-1337, (2006)

Sinus node inhibitors reduce the heart rate presumably by blocking the pacemaker current If in the cardiac conduction system. This pacemaker current is carried by four hyperpolarization-activated, cyc...

Use-dependent block of Ih in mouse dorsal root ganglion neurons by sinus node inhibitors.

Br. J. Pharmacol. 125 , 741-750, (1998)

1. The sinus node inhibitors UL FS 49 and DK-AH 269 reduce heart rate by slowing diastolic depolarization rate in the sino-atrial (SA) node, which might originate from the use-dependent blockade of a ...

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