HOPan

HOPan用途

HoPan抑制磷酸泛能酰半胱氨酸合成酶活性。

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HOPan名称

[ CAS 号 ]:
18679-90-8

[ 英文名 ]:
HOPan

[英文别名 ]:

hopantenic acid
HOPA
Homopantothenic acid
4-D-pantoylamino-butyric acid
D-Homopantothenic acid
Hopantenic
4-D-Pantoylamino-buttersaeure
HOPan

HOPan生物活性

[ 描述 ]:

HoPan抑制磷酸泛能酰半胱氨酸合成酶活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Mostert KJ, et al. The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity. ACS Chem Biol. 2021 Nov 19;16(11):2401-2414.

HOPan物理化学性质

[ 密度 ]:
1.23g/cm3

[ 沸点 ]:
556ºC at 760mmHg

[ 分子式 ]:
C₁₀H₁₉NO₅

[ 分子量 ]:
233.26

[ 闪点 ]:
290.1ºC

[ 精确质量 ]:
233.12600

[ PSA ]:
106.86000

[ 蒸汽压 ]:
1.11E-14mmHg at 25°C

[ 折射率 ]:
1.508

[ 储存条件 ]:
-20°C，干燥，密封

HOPan毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES9570000

CHEMICAL NAME :: Butyric acid, 4-(2,4-dihydroxy-3,3-dimethylbutyramido)-, D-(+)-

CAS REGISTRY NUMBER :: 18679-90-8

LAST UPDATED :: 198511

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H19-N-O5

MOLECULAR WEIGHT :: 233.30

WISWESSER LINE NOTATION :: QV3MVYQX1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,546,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5720 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BTMNA7 Bitamin. (Nippon Bitamin Gakkai, 4 Ushinomiya-cho, Yoshida, Sakyo-Ku, Kyoto 606, Japan) V.1- 1948- Volume(issue)/page/year: 25,297,1962

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HOPan安全信息

[ 海关编码 ]:
2924199090

HOPan合成路线

详细合成路线

HOPan上下游产品

HOPan上游产品

HOPan下游产品

HOPan海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%