(R)-(-)-NIGULDIPINE HYDROCHLORIDE

(R)-(-)-NIGULDIPINE HYDROCHLORIDE名称

[ CAS 号 ]:
189624-85-9

[ 英文名 ]:
(R)-(-)-NIGULDIPINE HYDROCHLORIDE

[英文别名 ]:

(S)-(+)-Watanidipine hydrochloride
BY 935
Watanidipine hydrochloride (S)-enantiomer
(S)-AE0047
(R)-Nigaldipine hydrochloride
(-)-Nigaldipine hydrochloride
B 8509-035

(R)-(-)-NIGULDIPINE HYDROCHLORIDE物理化学性质

[ 沸点 ]:
780.5ºC at 760 mmHg

[ 分子式 ]:
C₄₁H₄₄Cl₂N₄O₆

[ 分子量 ]:
759.71700

[ 闪点 ]:
425.8ºC

[ 精确质量 ]:
758.26400

[ PSA ]:
116.93000

[ LogP ]:
9.31740

[ 蒸汽压 ]:
2.62E-24mmHg at 25°C

(R)-(-)-NIGULDIPINE HYDROCHLORIDE毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7201200

CHEMICAL NAME :: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(4- (diphenylmethyl)-1-piperazinyl)phenyl)ethyl methyl ester, dihydrochloride, (S)-(+)-

CAS REGISTRY NUMBER :: 189624-85-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >12 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 25(Suppl 3),S745,1997 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 14850 ug/kg/9D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Blood - normocytic anemia Related to Chronic Data - death

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 25(Suppl 3),S793,1997

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相关化合物

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