BAY-598 R-isomer

BAY-598 R-isomer用途

BAY-598 R-isomer is the R-isomer of BAY589. BAY-598 R-isomer may be used as a reference compound. BAY-598 is a potent, peptide-competitive chemical probe for SMYD2. BAY-598 has a unique chemotype relative to the current SMYD2 chemical probe LLY-507. BAY-598 inhibits in vitro methylation of p53K370 with IC50 = 27 nM and has more than 100-fold selectivity over other histone methyltransferases and other non-epigenetic targets. BAY-598 inhibits the methylation of p53K370 in cells with IC50 < 1 μM. (Further to this, BAY-598 has properties that are compatible with in vivo experiments.) A control compound, BAY-369, has also been developed. BAY-369 inhibits the in vitro methylation of p53K370 with IC50 > 70 micromolar.

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BAY-598 R-isomer名称

[ CAS 号 ]:
1906920-28-2

[ 英文名 ]:
BAY-598 R-isomer

[英文别名 ]:

(R)-BAY-598

BAY-598 R-isomer物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
651.3±65.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₂₀Cl₂F₂N₆O₃

[ 分子量 ]:
525.335

[ 闪点 ]:
347.7±34.3 °C

[ 精确质量 ]:
524.094177

[ LogP ]:
2.43

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.629

BAY-598 R-isomer

BAY-598 R-isomer用途

BAY-598 R-isomer名称

BAY-598 R-isomer物理化学性质

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