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培西洛星

培西洛星用途

Variotin 是一种抗真菌 (Fungal) 剂。Variotin 对毛癣菌、小孢癣菌、表皮癣菌等皮肤癣菌,以及芽生菌、隐球菌等内部真菌病的致病真菌有较强的抗菌活性。

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培西洛星名称

[ CAS 号 ]:
19504-77-9

[ 中文名 ]:
培西洛星

[ 英文名 ]:
2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]-

[英文别名 ]:

Leofungine
Supral
EINECS 243-116-9
Pecilocin
variotin

培西洛星生物活性

[ 描述 ]:

Variotin 是一种抗真菌 (Fungal) 剂。Variotin 对毛癣菌、小孢癣菌、表皮癣菌等皮肤癣菌,以及芽生菌、隐球菌等内部真菌病的致病真菌有较强的抗菌活性。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. MATSUDA A, et al. Studies on antifungal activity of variotin. J Antibiot (Tokyo). 1959 Sep;12:203-9.

培西洛星物理化学性质

[ 密度 ]:
1.088g/cm3

[ 沸点 ]:
481.2ºC at 760mmHg

[ 分子式 ]:
C₁₇H₂₅NO₃

[ 分子量 ]:
291.39

[ 闪点 ]:
244.8ºC

[ 精确质量 ]:
291.18300

[ PSA ]:
57.61000

[ LogP ]:
2.68310

[ 蒸汽压 ]:
2.79E-11mmHg at 25°C

[ 折射率 ]:
1.538

培西洛星毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY5777000

CHEMICAL NAME :: 2-Pyrrolidinone, 1-(8-hydroxy-6-methyl-2,4,6-dodecatrienoyl)-, (E,E,E)-(R)-

CAS REGISTRY NUMBER :: 19504-77-9

LAST UPDATED :: 198104

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H25-N-O3

MOLECULAR WEIGHT :: 291.43

WISWESSER LINE NOTATION :: T5NVTJ AV1U2U1Y1&U1YQ4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,2004,1978