特戊酸氟米松

Flumethasone pivalate 是一种糖皮质激素和皮质类固醇酯。Flumetasone pivalate 具有抗炎、止痒和血管收缩活性。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 密度 ]:
1.27g/cm3

[ 沸点 ]:
600.3ºC at 760mmHg

[ 分子式 ]:
C₂₇H₃₆F₂O₆

[ 分子量 ]:
494.56800

[ 闪点 ]:
316.8ºC

[ 精确质量 ]:
494.24800

[ PSA ]:
100.90000

[ LogP ]:
3.44070

[ 蒸汽压 ]:
6.51E-17mmHg at 25°C

[ 折射率 ]:
1.55

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TU3832010

CHEMICAL NAME :

Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl-, 21-pivalate

CAS REGISTRY NUMBER :

2002-29-1

LAST UPDATED :

199710

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C27-H36-F2-O6

MOLECULAR WEIGHT :

494.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,705,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>5 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,705,1982

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S22-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TU3832010

特戊酸氟米松上游产品

特戊酸氟米松下游产品

Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation.

Int. J. Pharm. 370(1-2) , 181-6, (2009)

Charged drug delivery systems are interesting candidates for the delivery of drugs through skin. In the present study, it was possible to create negatively and positively charged oil/water nanoemulsio...

[Darkness effect in photochemotherapy. I. Effect of 8-methoxypsoralen on the epidermal patch test in allergic contact eczema].

Dermatol. Monatsschr. 169(1) , 46-8, (1983)

[Double-blind comparison of a betamethasone dipropionate-iodochloroxyquinoline combination and a flumethasone pivalate-iodochloroxyquinoline combination in the therapy of steroid-sensitive dermatoses with superinfection].

G. Ital. Dermatol. Venereol. 121(1) , XI-XIV, (1986)

更多文献

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区域：上海市普陀区

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